نتایج جستجو برای: interleukin 28b polymorphism
تعداد نتایج: 201199 فیلتر نتایج به سال:
Background: Investigating predictors of response to antiHCV therapy may avoid the current expensive therapy associated with various side effects. Aim of Work: To test for the hypothesis claiming that single nucleotide polymorphism (SNP) in the IL-28B gene might affect the response to antiviral treatment. The SNP rs12979860 C>T in the IL-28B gene was assayed, and its influence on response to HCV...
MicroRNAs (miRNAs) play critical roles in embryonic development and are frequently deregulated in human cancers. The let-7 family members are tumor-suppressing miRNAs and are frequently downregulated in cancer cells. Lin-28 and Lin-28B are RNA-binding proteins highly expressed in embryonic tissues. Lin-28 proteins block let-7 precursors from being processed to mature miRNAs by inducing terminal...
The rs12979860 single nucleotide polymorphism located on chromosome 19q13.13 near the interferon L3 gene (formerly and commonly known as interleukin 28B gene) has been associated in adults with both spontaneous and treatment induced clearance of hepatitis C virus. Although the exact mechanism of these associations remains unclear, it suggests that variation in genes involved in the immune respo...
background the hepatitis c virus (hcv) infection has been identified as a leading cause of progressive liver diseases worldwide. despite new treatment strategies, pegylated interferon alfa-2a (peg-ifnα-2a), in combination with ribavirin (rbv), still represents the gold standard of therapy for hepatitis c in developing countries. results in this study, a significant association was observed betw...
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