Periodontitis is caused by the inflammation of tooth-supporting tissue pathogens such as Aggregatibacter actinomycetemcomitans. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, triggers series inflammatory reactions and promotes bone resorption. The aim this study was to examine molecular mechanism anti-inflammatory function zingerone, dietary phenolic found in Zingiber officinale, on perio...

Abstract Objective In this study, we investigated the levels of interleukin‐1β (IL‐1β), IL‐18, and NOD‐like receptor pyrin domain‐containing 3 (NLRP3) inflammasome in patients with premature rupture membranes (PROMs). Methods We selected 60 pregnant women at Fourth Hospital Baotou between January 2019 July 2021. These were divided into three distinct groups: preterm PROM group 20 cases, term (T...

RINGKASAN - Tujuan penelitian ini untuk mengetahui hubungan kejadian Preeklamsia dengan mempertimbangkan jenis etnik atau suku ibu hamil berdasarkan kadar sitokin IL-1β dan IL-6 preeklampsia normotensi yang berada dI Pulau Sulawesi. Penelitian menggunakan case control pada di bugis, makassar, mandar, toraja. Pengambilan sampel dilaksanakan dirumah sakit puskesmas populasi 50 Preeklampsia 35 nor...

Since contradictory findings have been reported on potential effects of statins in modulating the inflammatory response, we have analysed the biological activity of lovastatin both in vitro using the Raw 264.7 murine macrophagic cell line and in vivo using BALB/c mice. When added to Raw 264.7 cells in combination with lipopolysaccharide, lovastatin significantly potentiated the release of inter...

Gout is an acute arthritis caused by the elevated levels of serum uric acid (UA), and its prevalence has been rapidly increasing. Alcohol abuse could lead to a series health problems. Multiple pieces evidence suggest that alcohol intake affects development progression gout, while gut microbiota plays important role in gout long-term consumption affect stability microbiota. This study aimed expl...

Background and Aim: Increased levels of receptor activator of nuclear factor kappa-B ligand (RANKL) and RANKL/OPG (osteoprotegerin) ratio in untreated periodontitis have been presented. However, current knowledge of periodontal treatment on osteoimmunological results is scarce. This study, aims to determine the RANKL, OPG, interleukin-1 beta (β), interleukin-10 levels in gingival crevicular flu...

Interleukin-1β (IL-1β) can limit tumor growth by promoting T cell-mediated antitumor immune responses. Several chemotherapeutic agents can stimulate the production of IL-1β by tumor-infiltrating leukocytes via the NLRP3 inflammasome. We have recently demonstrated that some chemotherapeutics can also trigger the secretion of IL-1β by driving the assembly of the caspase-8- and FADD-containing pla...

Abstract Background To describe the effect of mechanical ventilation on diaphragm mitochondrial oxygen consumption, ATP production, reactive species (ROS) generation, and cytochrome c oxidase activity content, their relationship to strength in an experimental model sepsis. Methods A cecal ligation puncture (CLP) protocol was performed 12 rats while controls underwent sham operation. Half each g...

Interleukin-1β (IL-1β) mediates many of the behavioral responses to infection and inflammation, and IL-1β-converting enzyme (ICE) processes intracellular IL-1β, leading to its maturation and secretion. Here we demonstrate that intracerebroventricular injections of lipopolysaccharide (LPS) produced a greater reduction in both food intake and food-motivated behavior in wild-type compared with ICE...