The molecular signaling events involved in the inhibition of breast cancer cell growth by retinoic acid and interferon-alpha were investigated. All-trans-retinoic acid and interferon-alpha acted synergistically to inhibit growth of both the estrogen receptor-positive breast cancer cell line MCF-7 and the estrogen receptor-negative line BT-20. In MCF-7 cells, all-trans-retinoic acid potentiated ...

The isolation of glucocorticoids (GC) was a tremendous achievement in the history medicine and had clinical impact similar to that discovery insulin or antibiotics. However, with expansion their use, multiple side effects have become evident even patients treated low doses. GC remain one main agents treatment systemic lupus erythematosus (SLE). studies genomic nongenomic justified use lower sta...

Earlier studies have shown that herpes simplex virus 1 (HSV-1) blocks the interferon response pathways, at least at two sites, by circumventing the effects of activation of protein kinase R by double-stranded RNA and interferon and through the degradation of promyelocytic leukemia protein (PML) since interferon has no antiviral effects in PML(-/-) cells. Here we report on two effects of viral g...