Suxamethonium and auditory evoked potentials Sir,—I read with interest the article by Brunner and colleagues on the relationship between suxamethonium and cortical auditory evoked potentials [1]. The focus of the article was the hypothesis that suxamethonium may cause arousal of anaesthetized patients, but no plausible explanations were offered by the authors as to the possible mechanism. I sus...

R. E. Thayer (1989) proposed 2 types of activation: energetic arousal (awake-tired) and tense arousal (tense-calm). This view has been challenged by claims that energetic arousal and tense arousal are mixtures of valence and a single activation dimension. The authors present a direct test of this hypothesis by computing the correlation between the residuals of energetic arousal and tense arousa...

Lexical decisions to high- and low-arousal negative words and to low-arousal neutral and positive words were examined in an event-related potentials (ERP) study. Reaction times to positive and high-arousal negative words were shorter than those to neutral (low-arousal) words, whereas those to low-arousal negative words were longer. A similar pattern was observed in an early time window of the E...

Objective: To examine the efficacy and safety of non-pharmacological non-ablative options (or a combination these) for postmenopausal dyspareunia. Mechanism: Narrative review on Findings in Brief: Dyspareunia is most bothersome symptom genitourinary syndrome menopause, often complicated by decreased sexual interest arousal. Solid-state vaginal laser (SSVL) recombinant platelet-derived epidermal...

Planning and readiness for action are associated with pre-movement brain activity reflected in the readiness potential (RP). Previous research suggests that RP is affected by higher-order cognitive functions. The present study investigated the relationship between arousal and RP. Twenty participants performed a RP paradigm in which they executed self-paced movements approximately every 4-5s. Pa...

Paraphilia refers to the intense and persistent sexual interest and arousal towards objects, situations or individuals which are atypical, equal to and/or greater than normophilic sexual interests [1]. Paraphilic disorders in the DSM-5 include exhibitionism, fetishism, peadophilia, sexual masochism, sexual sadism, transvestic fetishism and voyeurism possess a formal diagnostic criteria (APA, 20...

Arousal is fundamental to many behaviors, but whether it is unitary or whether there are different types of behavior-specific arousal has not been clear. In Drosophila, dopamine promotes sleep-wake arousal. However, there is conflicting evidence regarding its influence on environmentally stimulated arousal. Here we show that loss-of-function mutations in the D1 dopamine receptor DopR enhance re...