Mitochondrion, an organelle with two layers of membrane, is extremely vital to eukaryotic cell. Its major functions are energy center and apoptosis censor inside cell. The intactness of mitochondrial membrane is important to maintain its structure and function. Mitophagy is one kind of autophagy. In recent years, studies of mitochondria have shown that mitophagy is regulated by various factors ...

Human RNase P is implicated in transcription of small non-coding RNA genes by RNA polymerase III (Pol III), but the precise role of this ribonucleoprotein therein remains unknown. We here show that targeted destruction of HeLa nuclear RNase P inhibits transcription of 5S rRNA genes in whole cell extracts, if this precedes the stage of initiation complex formation. Biochemical purification analy...

Glycoprotein (GP) Ibalpha is the functionally dominant subunit of the platelet GPIb-IX-V receptor complex, with the von Willebrand factor (vWF) binding site residing on the amino-terminus. A threonine for methionine-145 replacement of GPIbalpha is associated with the human platelet antigen (HPA)-2 system. To study the structural and functional consequences of this mutation, both forms of GPIbal...

Fish mucosal surface is a significant interface for pathogens to infect from an aqueous environment. In addition innate and adaptive immune factors, epithelial cells are considered as physical barrier against microbial invasion. Previously, we identified mammalian CD46-like complement regulatory protein (Tecrem) in teleost detected its expression on derived fin, suggesting physiological role th...

Global change increasingly threatens nature, endangering the ecosystem services human wellbeing depends upon. Biodiversity potentially mediates these impacts by providing resilience to ecosystems. While biodiversity has been linked and service supply on smaller scales, we lack understanding of whether mediating interactions between anthropogenic drivers are global ubiquitous, how they might dif...

Abstract For tribes whose preservation values and mitigation strategies for managing cultural heritage are built on an ethic of avoidance minimal disturbance, geophysical technologies can be key components the research design. These technologies, most notably ground-penetrating radar, have been used with great success in identifying evaluating depth, extent, composition some those resources man...

Abstract Aim of this work is to apply protective and homogeneous shellac coating layers on the surface hydrophilic open-pore cellulose aerogel particles with low densities ? 0.1 g/cm 3 high specific areas in range ~ 400–450 m 2 /g while keeping aerogels’ microstructure intact during processing. For purpose, an innovative miniaturized spouted bed setup was used. Successful process settings for a...

Intact spinach (Spinacia oleracea) chloroplasts, thylakoid membranes, and inside-out or right-side-out thylakoid vesicles have been characterized by flow cytometry with respect to forward angle light scatter, right angle light scatter, and chlorophyll fluorescence. Analysis of intact chloroplasts with respect to forward light scatter and the chlorophyll fluorescence parameter revealed the prese...