Geohelminth infections are associated with modulation of immunity to parasite antigens and aeroallergens. To investigate the possibility that this modulation is affected by anthelmintic treatment, we compared cytokine responses in children who were treated with repeated doses of albendazole over 1 year versus those in children who had were not treated. Whole-blood samples were cultured with Asc...

Summary Eosinophilic esophagitis (EoE) is an increasingly frequent diagnosis in our clinical practice, mainly in pediatric age. Allergic responses to food and aeroallergens have been increasingly implicated in the etiology of this disease. We describe a retrospective data analysis of pediatric EoE patients followed in our Immunoallergology Department. Of the 25 children (22 male, average 10.8 y...

Local allergic rhinitis is a newly described type of rhinitis involving nasal production of specific immunoglobulin (slg) E antibodies in the absence of atopy. It can affect patients previously diagnosed with non-allergic rhinitis. Evidence for this entity is supported by clinical symptoms, local production of slgE, a type 2 helperT cell inflammatory pattern in nasal secretions during natural e...

BACKGROUND Atopic dermatitis (AD) is known to predate asthma and other atopic disorders described under the term "atopic march". However, this classic sequence is not always present and only a few studies have addressed children at risk of developing asthma. The objective of this study is to define early-onset AD phenotypes leading to asthma. METHODS We performed a cluster analysis with 9 var...

OBJECTIVES To assess the kind and frequency of sensitisation to aeroallergens (skin prick test - SPT) of asthmatic and non-asthmatic adolescents (13-14 years old) living in the city of Caruaru, Northeast of Brazil, and to analyse their exposure to some environmental factors. METHOD A case-control study was conducted with asthmatic (50) and non-asthmatic (150) adolescents diagnosed by the Inte...

Subclinical inflammation in gut mucosa has been demonstrated in bronchial asthma suggesting the whole mucosal system is involved in allergic diseases. The presence of subclinical bronchial involvement was assessed by nonspecific bronchial hyperresponsiveness (BHR) in nonasthmatic patients with food allergy (FA). BHR was studied in 35 patients with various manifestations of FA without food-induc...

BackgroundAllergic disorders are the consequence of IgE sensitization to allergens. Population studies have shown that certain human leukocyte antigen (HLA) alleles associated with increased or decreased risk developing allergy.ObjectiveWe aimed characterize relationship between HLA class II allelic diversity and in an understudied Arab population.MethodsWe explored associations 7 allergen mixe...

Results Of 1860 patients screened, 1097 (58.9 %) gave history of food allergy. Of the history positive patients 470 were skin prick tested . 29.3 % (138/470) exhibited positive reactions to one or more food(s). Rice elicited SPT positive reaction in maximum ( 6.2 %) cases followed by blackgram (5.9 %), lentil (5.5 %), citrus fruits (5.3 %), pea (3.8 %), maize (3.8%) and banana (3.6 %). Among fo...

Kashmir valley has been witnessing an increase in allergy related disorders usually due to aeroallergens present in the environment mostly during spring and autumn seasons. The present study was aimed at finding total and specific IgE responses in serum samples of 257 patients reporting to various health centers across the valley with symptoms of seasonal allergy. Samples were first screened fo...

these were similar between all groups.When comparisons were made between the groups, these areas showed statistically significant differences: 1) Practitioners who see more patients with EoE more frequently were more likely to perform testing for immediate hypersensitivities to aeroallergens and foods. 2) Practitioners who participate more often in workshops were less likely to perfrom patch te...