Centromeric DNA forms two structures on the mitotic chromosome: the kinetochore, which interacts with kinetochore microtubules, and the inner centromere, which connects sister kinetochores. The assembly of the inner centromere is poorly understood. In this study, we show that the human Mis14 (hMis14; also called hNsl1 and DC8) subunit of the heterotetrameric hMis12 complex is involved in inner ...

Recent years have witnessed that iterative Krylov methods without re-designing are not suitable for distribute supercomputers because of intensive global communications. It is well accepted that re-engineering Krylov methods for prescribed computer architecture is necessary and important to achieve higher performance and scalability. The paper focuses on simple and practical ways to re-organize...

In this paper, a new, high-speed multiplication algorithm using tree circuit and a novel inner product generator has been presented. In inner product generation step, a new Smith algorithm has been modified. In inner product reduction step, a new array structure has been proposed. In final addition step, a new algorithm has been used. In this work, improvements in multiplication algorithm by us...

XParts is an UML-based architecture description language and an application framework for Java applications. It is a simple extension of the Java language by providing an architecture model descriptor. The architecture description utilizes UML component diagrams and gives it a simple, precise, and feasible semantics. An application interprets the model descriptor. Hence, there is no gap between...

the effect of triton x-100, na cholate and tween 80 on the solubilization of integral membrane proteins in intact cells, spheroplasts and inner-membrane fragments of salmonella typhimurium was studied. the detergents were used in various concentrations (1.6 to 64 mm) and cytochromes b and d were used as marker to monitor the solubilization of membrane-bound proteins. results showed that no inne...

this paper seeks to investigate a new definition for architecture by unifying the three vitruvian principles of firmitas, utilities, and venustas via a phenomenological approach in the interpretation and analysis of their role in defining architecture. the paper is composed in two main sections. the first section investigates the nature of architecture based on the mentioned principles, where a...

Games and video games entertain us and allow us to socialize and learn. Trying to take advantage of the interest in them and their characteristics as tools for education, the development of Serious Games has become popular. This paper presents the GAMeNT Framework which consists of an architecture and a methodology that guide the design and development of Serious Games. This framework was devel...

Sound measurement of intelligence cannot be reduced to just measurement of performance. It is necessary to measure the real capabilities of the behavior generation engine of machines to be able to determine with precision their suitability for any particular task. We will see that it is necessary to focus on the architecture of the systems. The paper will present a summarial description of inne...

We present a schema-based agent architecture which is inspired by an ethological model of the praying mantis. It includes an inner state, perceptual and motor schemas, several routines, a fovea and a motor. We describe the design and implementation of the architecture and we use it for comparing two models: the former uses reactive, stimulusresponse schemas; the latter involves also forward mod...

during the past several decades, neighborhoods have experienced gentrification phenomenon in a number of cities. gentrification, the process of neighborhood change that results in the replacement of lower income residents with higher income ones, has altered the character of hundreds of urban neighborhoods in many north american and european cities. in this paper we state how does gentrificatio...