Vascular smooth muscle cells (VSMCs) hyperplasia is a common feature of pathologic cardiovascular event such as restenosis and atherosclerosis. The role and mechanisms of microRNAs (miRs) in VSMCs proliferation are poorly understood. Here, we report that miR-181b promotes VSMCs proliferation and migration. In an animal model, miR-181b was significantly increased in the rat carotid artery after ...

The rise in DNA synthesis in regenerating rat liver is inhibited by azathioprine (40 mg/kg). Regeneration in the presence of azathioprine occurs by hypertrophy as assessed both by an increase in the ratio of RNA or protein to DNA and by an increase in diameter of the hepatocytes. Mitoses that occur in azathioprine-treated regenerating liver result from a G2 population that is apparently stimula...

signal transducers and activators of transcription (stats) are cytoplasmic transcription factors that have a key role in cell fate. stats, a protein family comprised of seven members, are proteins which are latent cytoplasmic transcription factors that convey signals from the cell surface to the nucleus through activation by cytokines and growth factors. the signaling pathways have diverse biol...

Previous studies indicate that organ fibroblasts play an important role in wound healing, collagen production, remodeling processes and pathogenesis of progressive heart, lung, renal and hepatic fibrotic diseases. Several studies suggest a possible inhibitory role for adenosine in the regulation of fibroblast proliferation. The effect of adenosine A2 agonists on proliferation and differentiatio...

Experiments using rubber/resin foam (RB) have already shown that far-infrared rays suppress the proliferation of cancer cells. We will report as a follow up to these findings. When RB was used, temperature culture solution increased by about 0.4°C. This time, with focus on this rise, new heating plate manufactured, and experiments were conducted without RB. It determined suppression growth beca...