Smoke inhalation is a common cause of cyanide poisoning during fires, resulting in injury and even death. In many cases of smoke inhalation, cyanide has increasingly been recognized as a significant toxicant. The diagnosis of cyanide poisoning remains very difficult, and failure to recognize it may result in inadequate or inappropriate treatment. Findings suggesting cyanide toxicity include the...

While several recent reports have described the toxicity of water-soluble C60 fullerene nanoparticles, none have reported the toxicity resulting from the inhalation exposures to C60 fullerene nanoparticles or microparticles. To address this knowledge gap, we exposed male rats to C60 fullerene nanoparticles (2.22 mg/m3, 55 nm diameter) and microparticles (2.35 mg/m3, 0.93 microm diameter) for 3 ...

Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO(2) (concentration range studied: 40-1,000 p.p.m.) increases death rates due to H(2)O(2) stress in Escherichia coli in a dose-specific manner. This effect is correlated with an increase in H(2)O(2)-induced mutagenesis and, as shown by 8-oxo-guanine determinations in cell...

The physical and chemical properties of an aerosol have a direct influence upon fire suppression mechanisms and extinguishing efficacy. These same properties are also basic determinants of aerosol inhalation toxicity. To evaluate the toxicity of an aerosol, it must first be determined if the aerosol can be inspired. Particles with a median aerodynamic diameter of 1-2 pm are capable ofpenetratin...

ALCOHOLS  The lower aliphatic alcohols are low to moderately toxic and usually have low vapor pressures, therefore inhalation toxicity is low.  Vapors may be an irritant to the eyes and mucous membranes.  Ingestion and absorption of the liquids through the skin can be a major health hazard.  Lower alcohols containing double or triple bonds exhibit a greater degree of toxicity and irritation...

The isocyanates are widely used as precursors of polyurethane products, as well as carbamate insecticides. Toluene 2,4-diisocyanate (TDI) is one of the most important commercially used isocyanates. Humans may be exposed to TDI by inhalation, ingestion, dermal and eye contact. TDI is a powerful irritant to the mucosal membranes of the gastrointestinal and respiratory tracts, eyes and the skin. P...

Explanation.................................................................................................... 203 Evaluation for acceptable daily intake .......................................................... 204 Biochemical aspects ................................................................................ 204 Absorption, distribution and excretion ......................................

Plastic costume masks regularly exhibit unpleasant odors that may be associated with the emissions of volatile organic compounds (VOCs). Upon inhalation, VOCs might adversely affect wearer’s health if exposure exceeds regulatory threshold values. The emitted from a selection (n = 12) were characterized semiquantitatively screening method based on GC/MS measurements in dynamic headspace sampling...