Intracellular Ca(2+)-binding S100A8/A9 proteins gain novel functions when released during inflammation. The exact outcome of their extracellular function depends on the local tissue environment in which they are released; both anti-inflammatory and pro-inflammatory responses are described, modulating the immune system by binding Toll-like receptor (TLR)-4 or the receptor for advanced glycation ...

sleep plays a vital role in regulating physiological mechanisms in the human body. nowadays, by the change of lifestyle and as a consequence of longer work hours and increased accessibility to media, sleep disturbance becomes a common problem in modern society. many studies demonstrated that sleep disturbance triggers a systemic low-grade inflammation by increasing the level of several cytokine...

Coronaviruses disease (COVID-19) vaccines have emerged worldwide to control this illness, albeit they cannot guarantee full effectiveness. Polyphenols possess antioxidant, anti-inflammatory, and antiviral properties, all of which may be effective against COVID-19 symptoms. Since polyphenols exhibit low bioavailability, nano-formulation (a food technology) been utilized in patients. Therefore, t...

Objectives and background Recently, a possible role of circadian system in the pathogenesis various gastrointestinal disorders gained an attention. The association with immune activity reciprocal connection intestinal microbiota indicate links inflammatory bowel diseases (IBD). Methods retrospective study provided semiquantitative immunohistochemical analysis expression 8 core proteins (BMAL1, ...

Inflammation is a normal protective reaction against tissue damage caused by physical injury, harmful chemicals, and protein denaturation. Protein denaturation process in which proteins lose their tertiary structure secondary due to foreign substances, external compounds, such as strong acids, bases, organic salts, solvents, heating. The purpose of this study was determine the anti-inflammatory...

Histone acetylation regulates activation and repression of multiple inflammatory genes known to play critical roles in chronic inflammatory diseases. However, proteins responsible for translating the histone acetylation code into an orchestrated proinflammatory cytokine response remain poorly characterized. Bromodomain and extraterminal (BET) proteins are "readers" of histone acetylation marks,...

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-strand RNA virus belonging to the Coronaviridae family, responsible for infectious disease 2019 (COVID-19) with rapid transmission. This study aimed characterize and compare SARS-CoV-2 SARS-CoV major viral proteins predict antigen proteasomal cleavage patterns, MHC class I processing presentati...