نتایج جستجو برای: inducible nitric oxide synthase inos

تعداد نتایج: 275550  

1998
N Leonard A E Bishop J M Polak I C Talbot

Aim—To examine the eVect of corticosteroid treatment on the expression of inducible nitric oxide synthase (iNOS) in the colon of patients with inflammatory bowel disease. Methods—Four groups of patients were studied: (1) ulcerative colitis treated with high dose corticosteroids (six patients, 10 blocks); (2) ulcerative colitis patients who had never received corticosteroids (10 patients, 16 blo...

Journal: :The Journal of urology 2008
L Renström Koskela T Thiel I Ehrén P J De Verdier N P Wiklund

PURPOSE Interstitial cystitis is a chronic inflammatory disease of the bladder and luminal nitric oxide has been shown to be increased in the bladder in patients with interstitial cystitis. We analyzed endogenous nitric oxide formation and inducible nitric oxide synthase gene expression in the bladder of patients with interstitial cystitis to obtain further knowledge of the localization of indu...

Journal: :Open Access Macedonian Journal of Medical Sciences 2022

BACKGROUND: Interleukin-6 (IL-6) and inducible Nitric oxide Synthase (iNOS) have an effect on neuropathic pain in the inflammatory process peripheral nerve injuries. AIM: This study aims to examine of anti-IL-6 receptor antibody IL-6 iNOS levels as a consideration for treatment rat model injury. METHODS: Twenty-eight young adult male Wistar rats were treated injury then divided into two groups....

Journal: :Clinical science 2001
M J Hickey

Constitutively produced nitric oxide released by endothelial cells has been shown to act as an endogenous agent which inhibits the rolling and adhesion of leucocytes in the microcirculation. However, during various types of inflammation, expression of the inducible form of nitric oxide synthase (iNOS) can dramatically increase the amount of nitric oxide present in tissues. Furthermore, as iNOS ...

2013
Antoaneta Belcheva Blerta Green Ashley Weiss Catherine Streutker Alberto Martin

Gut microbiota has been linked to a number of human diseases including colon cancer. However, the mechanism through which gut bacteria influence colon cancer development and progression remains unclear. Perturbation of the homeostasis between the host immune system and microbiota leads to inflammation and activation of macrophages which produce large amounts of nitric oxide that acts as a genot...

Objective(s):The neuropeptide calcitonin gene-related peptide (CGRP) has long been postulated to play an integral role in the pathophysiology of migraine. Earlier studies showed that CGRP can stimulate the synthesis and release of nitric oxide (NO) and cytokines from trigeminal ganglion glial cells. The purpose of this study was to determine the effect of 17β-estradiol in regulation of CGRP exp...

A Hosseini A Hosseini-Sharifabad A Kazemi A Kebriaeezadeh K Azami K Tabrizian M Belaran M Sharifzadeh M Soodi S Najafi

Nitric oxide (NO) is thought to be involved in spatial learning and memory in several brain areas such as hippocampus. This study examined the effects of post-training intrahippocampal microinjections of 1400W as a selective inducible nitric oxide synthase (iNOS) inhibitor on spatial memory, in both anesthetized and non-anesthetized situations in rats. In the present work, 4-day training trials...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2008
Ivan T Demchenko Dmitriy N Atochin Diana R Gutsaeva Ryan R Godfrey Paul L Huang Claude A Piantadosi Barry W Allen

Reactive species of oxygen and nitrogen have been collectively implicated in pulmonary oxygen toxicity, but the contributions of specific molecules are unknown. Therefore, we assessed the roles of several reactive species, particularly nitric oxide, in pulmonary injury by exposing wild-type mice and seven groups of genetically altered mice to >98% O2 at 1, 3, or 4 atmospheres absolute. Genetica...

Journal: :Journal of clinical pathology 1998
N Leonard A E Bishop J M Polak I C Talbot

AIM To examine the effect of corticosteroid treatment on the expression of inducible nitric oxide synthase (iNOS) in the colon of patients with inflammatory bowel disease. METHODS Four groups of patients were studied: (1) ulcerative colitis treated with high dose corticosteroids (six patients, 10 blocks); (2) ulcerative colitis patients who had never received corticosteroids (10 patients, 16 ...

2016
Ratnadeep Mukherjee Diwakar Kumar Singh Pijus Kanti Barman Birendra Kumar Prusty Pravat Thatoi Rina Tripathy Bidyut Kumar Das Balachandran Ravindran

Nitric oxide performs a wide variety of versatile functions in the immune system. But it's precise role in the pathogenesis of acute inflammation and sepsis is still controversial. In the present study, we demonstrate a novel mutation in nitric oxide synthase interacting protein (NOSIP) and its association with mortality in sepsis. We also show direct physical interaction of NOSIP with inducibl...

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