Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate effect of PRDX1 on EMT airway epithelial cells stimulated with lipopolysaccharide (LPS) transforming growth factor-beta (TGF-β1). overexpression significantly increased proliferation migration human bronchial (BEAS-...

We have previously shown that the proliferative response of T cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (CR) attenuated the age-related decline in proliferation and IL-2 expression. Because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...

apoptosis, a physiologic mechanism to eliminate unwanted cells, is also induced by ionizing irradiation, through production of free radicals. it has been demonstrated that antioxidants such as vitamin e are able to protect cells from damage caused by free radicals. taken together we found it reasonable to make an attempt to evaluate the protective effect of vitamin e against apoptosis. the irra...

introduction: lead toxicity induces retinal cell apoptosis. vitamin c and garlic may decrease lead-induced apoptosis. this study was undertaken to investigate vitamin c and garlic protective effects on lead-induced apoptosis in eye retina. methods: pregnant wistar rats (n = 72) were divided randomly into 9 groups: (l) treated rats with lead acetate in drinking water and (l+aa) with leaded water...

Objective(s): Osteoarthritis (OA), characterized by degradation of articular cartilage, is a leading cause of disability. As the only cell type present in cartilage, chondrocytes play curial roles in the progression of OA. In our study, we aimed to explore the roles of miR-23b in the lipopolysaccharide (LPS)-induced inflammatory injury. Materials and Methods: LPS-induced cell injury of ATDC5 ce...

objective(s): this study focused on determining cytotoxic effects of copper oxide nanoparticles (cuo nps) on chronic myeloid leukemia (cml) k562 cell line in a cell-specific manner and its possible mechanism of cell death. we investigated the cytotoxicity of cuo nps against k562 cell line (cancerous cell) and peripheral blood mononuclear cell (normal cell). materials and methods: the toxicity w...

Background and objectives: Oxidative stress is implicated in the neuronal damage associated with Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotropic lateral sclerosis and cerebral ischemic stroke. The present work was designed to establish the neuroprotective effects of Salvia aristata extract on H2O2-induced apoptosis in human dopaminergic ...