Glutathione (GSH) is a tripeptide and a superoxide radical scavenger and it protects thiol protein groups required for maintaining the integrity of cell against oxidation. GSH is present in the stomach at high concentrations and plays an important role in maintaining the integrity of the gastric mucosa. We investigated whether oral administration of nimesulide, rofecoxib and celecoxib, selectiv...

Chromobacterium violaceum, Gram-negative bacteria species found in tropical regions of the world, produces a distinct deep violet-colored pigment called violacein. In the present study, we investigated whether violacein can promote a gastroprotective effect and verified the possible mechanisms involved in this action. For this study, an indomethacin-induced gastric ulcer rat model was used. The...

BACKGROUND Korean red ginseng (KRG) is a ginseng that has been cultivated and aged for 4-6 years or more, and goes through an extensive cleaning, steaming and drying process. KRG contains more than 30 kinds of saponin components and has been reported as having various biological properties, such as anti-fatigue action, immune restoration, and neurovegetative effect. The purpose of this study wa...

BACKGROUND/AIMS Aging gastric mucosa is known to have decreased mucosal defenses and increased susceptibility to injury by nonsteroidal anti-inflammatory drugs. Depending on the type of nonsteroidal anti-inflammatory drug (NSAID), the underlying mechanisms and the extent of damage to the stomach or intestine may differ. This study was performed to evaluate the acute gastric damage caused by dif...

Glutathione (GSH) is a tripeptide and a superoxide radical scavenger and it protects thiol protein groups required for maintaining the integrity of cell against oxidation. GSH is present in the stomach at high concentrations and plays an important role in maintaining the integrity of the gastric mucosa. We investigated whether oral administration of nimesulide, rofecoxib and celecoxib, selectiv...

glycyrrhiza glabra l. is used in folk medicine for treatment of stomach disorders includingpeptic ulcers. the hydroalcoholic extract of glycyrrhiza glabra l. (hegg) was evaluated forantiulcerogenic activity and acute toxicity profile in mice. various doses of hegg (50-200mg/kg) were administered orally to animals of different groups. omeprazole and cimetidine atdoses of 30 and 100 mg/kg were us...

Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders includingpeptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated forantiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG (50-200mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine atdoses of 30 and 100 mg/kg were us...

Objective: An ethanolic extract of Sesamum indicum Linn was used to test for phytochemicals, antioxidant activity, and gastroprotective effects. Study Design: Cross-Sectional Place Study: Rashid Latif Medical College Lahore. Duration July 2021 March 2022 Materials methods: This study ulcerated Wister albino rats using pylorus ligation indomethacin-induced ulcer screening. Ulceration required li...

The healing activities of black tea (BT) and the theaflavins (TF) against the indomethacin-induced stomach ulceration were studied in a mouse model. Indomethacin (18 mg/kg, p.o.) administration induced maximum ulceration in the glandular portion of the gastric mucosa on the 3rd day, accompanied by increased lipid peroxidation and protein oxidation, depletion of thiol-defense and mucin, as well ...