نتایج جستجو برای: indole
تعداد نتایج: 10457 فیلتر نتایج به سال:
Indole is emitted from the biosphere by plants under stressed conditions. The SOA yield of Indole was measured in a smog chamber. The particles were collected and the mass absorption coefficient determined at various wavelengths. With nanospray desorption electrospray high resolution mass spectrometry and DART-MS the molecular formula of a series of species in the aerosol phase was identified a...
Indole is emitted from the biosphere by plants under stressed conditions. The SOA yield of Indole was measured in a smog chamber. The particles were collected and the mass absorption coefficient determined at various wavelengths. With nanospray desorption electrospray high resolution mass spectrometry and DART-MS the molecular formula of a series of species in the aerosol phase was identified a...
The ability of indole derivatives to facilitate RNA polymerase transcription of the L-arabinose operon in Escherichia coli was shown to require the catabolite activator protein (CAP) as well as the araC gene product. Adenosine 3',5'-monophosphate (cAMP) was not obligatory for araBAD transcription when the cells were grown in the presence of 1 mM indole-3-acetic acid or in the presence of indole...
Seaweed, a popular and abundant food ingredient mainly consumed in Asian countries, is a good source of bioactive compounds with anti-obesity effects. However, the anti-obesity effects of Sargassum thunbergii have not yet been established. In this study, we isolated six indole derivatives (STCs)-indole-2-carboxaldehyde (STC-1), indole-3-carboxaldehyde (STC-2), indole-4-carboxaldehyde (STC-3), i...
FILDES [1938], referring to the claims of Happold & Hoyle [1936] that 'the failure to produce indole by cultures of E. coli grown in the presence of glucose is due to the non-production of a tryptophanase system', suggests that this is but a partial truth and that the tryptophanase system in the cells consists oftwo parts, a ' constitutive' part and an 'adaptive' part, ofwhich only the 'adaptiv...
This report describes that a regular positive electrospray ionization mass spectrometry (MS) analysis of terpendoles often causes unexpected oxygen additions to form [M + H + O](+) and [M + H + 2O](+), which might be a troublesome in the characterization of new natural analogues. The intensities of [M + H + O](+) and [M + H + 2O](+) among terpendoles were unpredictable and fluctuated largely. S...
The bis indole sponge alkaloid dragmacidin E was synthesized in racemic form over 25 steps starting from 7-benzhydroxyindole. Key steps include (a) a Witkop cyclization to facilitate construction of the indole-spanning seven-membered ring and (b) a cyclodehydrative pyrazinone synthesis that unites the two indole-containing sectors.
Development of novel synthetic methodologies and their application to synthesis of natural products are described. The first topic is about an extension of the scope of our indole synthesis by radical cyclization of o-alkenylphenyl isocyanides. By utilizing this methodology and nitrogenzenesulfonamide chemistry, an efficient total synthesis of hexacyclic aspidosperma indole alkaloid, aspidophyt...
Indole alkaloids are well characterized for diverse activities. Meanwhile, the present scenario of disease depicting a different story, urge a call for novel scaffolds and pharmacophores. In recent years, indole based alkaloids gain significant importance in cancer chemotherapy and used as an adjuvant especially in case of Vinca alkaloids. These reports encourage the researchers for new finding...
A series of N-(aminoiminomethyl)-1H-indole carboxamide derivatives were synthesized and their inhibitory potencies against the Na+/H+ exchanger were measured. Variation of the carbonylguanidine group at the 2- to 7-position of the indole ring system showed that a substitution at the 2-position improved the Na+/H+ exchanger inhibitory activity the most in vitro. This led to the synthesis and eva...
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