Hourly rounds—intentionally checking on patients at regular intervals—continues to be debated in nursing circles. Often, registered nurses make rounds on even hours and support staff make rounds on odd hours from 6 AM to 10 PM (and every 2 hours from 10 PM to 6 AM). While making rounds, staff engage patients by checking on the “4 P’s”: pain, positioning, potty (elimination), and proximity of pe...

The catalogue of tumour-specific somatic mutations (SMs) is growing rapidly owing to the advent of next-generation sequencing. Identifying those mutations responsible for the development and progression of the disease, so-called driver mutations, will increase our understanding of carcinogenesis and provide candidates for targeted therapeutics. The phenotypic consequence(s) of driver mutations ...

We present a large number of examples of sidechain interactions in which it appears at first that highly unfavorable positive charges are in close proximity. In particular, we examine pairs of arginines (resp., lysines) whose sidechain Cζ (resp., Nζ) atoms are very close. We screen PDB files to find such pairs for which there are no plausible counter ions. On the other hand, we show that invari...