OBJECTIVE To determine the cost effectiveness of several cervical cancer screening strategies utilizing HPV testing in South Africa. METHODS We developed a lifetime Markov model of the costs, quality of life, and survival associated with screening and treating cervical cancer and its precursors. Screening strategies evaluated included: 1) conventional cytology, 2) cytology followed by HPV tes...

BACKGROUND Primary aldosteronism (PA) is a common and underdiagnosed disease with significant morbidity potentially cured by surgery. We aim to assess if the long-term cardiovascular benefits of identifying and treating surgically correctable PA outweigh the upfront increased costs in patients at the time patients are diagnosed with resistant hypertension (RH). METHODS AND RESULTS A decision-...

the primary purpose of this paper is to highlight for the research community and practitioners the various aspects of using vmi-type supply chains in today’s business environment as well as a number of directions for future studies. in this regard, fifty articles published in major international journals, beginning in 1995, which contribute to the vmi-type supply chains are reviewed via a syste...

Early attempts to formulate information systems (IS) strategies concentrated on the analytical task of deriving IS strategies from business plans. The limitations of the static plans that often resulted from these formal studies were, however, soon discovered. The critics suggested informal and incremental planning to ensure flexibility, creativity and strategic thinking to comprise emergent st...

We present the first study employing Bayesian modelling of isotopic measurements on dentine increments (five human upper molars) to address Romano-British infant feeding practices at Bainesse (UK). The stable carbon and nitrogen isotope results modelled 6-month intervals with novel OsteoBioR software revealed some common patterns, weaning not starting before age 6 months higher animal protein c...