INTRODUCTION There is an urgent need to develop new treatments for Alzheimer's disease (AD) and to understand the drug development process for new AD therapies. METHODS We assessed the agents in the AD pipeline as documented in clinicaltrials.gov for phase I, phase II, and phase III, accessed 1/5/2017. RESULTS There are 105 agents in the AD treatment development pipeline, of which 25 agents...

immunohistochemical analysis against Arc protein was used to test whether a change in the CS–US interval (resulting in a new memory formation for duration) triggers plasticity in the dorsal striatum. In a similar fashion, the “time-shift paradigm” provides a powerful tool for isolating the role of Glu in the formation of memory for target durations. Recently, we examined the effect of intraperi...

Recent work has shown that zinc is involved in the developmental regulation of neurotrophins and N-methyl-D-aspartate (NMDA) receptors, controlling use of glutamate as a neurotransmitter in the central nervous system (CNS). This is particularly important in the hippocampus, a region of the brain involved in learning and memory, and is an intriguing link to the role of zinc in neuropsychological...

 Let $R$ be a ring‎, ‎and let $n‎, ‎d$ be non-negative integers‎. ‎A right $R$-module $M$ is called $(n‎, ‎d)$-projective if $Ext^{d+1}_R(M‎, ‎A)=0$ for every $n$-copresented right $R$-module $A$‎. ‎$R$ is called right $n$-cocoherent if every $n$-copresented right $R$-module is $(n+1)$-coprese-nted‎, ‎it is called a right co-$(n,d)$-ring if every right $R$-module is $(n‎, ‎d)$-projective‎. ‎$R$...

background: peripherally inserted central catheter (picc) is commonly used in nursing for patients with leukemia. the purpose of this study was to investigate the risk factors of catheter-related infection (cri) in patients with leukemia and to provide some nursing strategies based on the results. methods: clinical data from 140 patients with leukemia between may 2014 and july 2016 in haiyang p...

This article discusses the anesthetic management and implications of 2 pediatric patients with a diagnosis of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. Anti-NMDA receptor encephalitis has been described as an immune-meditated syndrome that triggers the production of antibodies to the NMDA receptor: a site of action for many commonly used anesthetic agents. Symptoms of this disease...

The transfer of an acetyl group from acetyl-CoA to an acceptor amine is a ubiquitous biochemical transformation catalyzed by Gcn5-related N-acetyltransferases (GNATs). Although it is established that the reaction proceeds through a sequential ordered mechanism, the role of the acetyl group in driving the ordered formation of binary and ternary complexes remains elusive. Herein, we show that CoA...