REVIOUS studies of DAVIDSOHN and STERN (1949, 1950) and of STERN and P DAVIDSOHN (1954) have demonstrated significant differences in distribution of titers of natural agglutinins for sheep red cells within and between inbred strains of mice. Results obtained on substantial numbers of mice of 13 strains are summarized in table 1. These mice, which consisted of approximately equal numbers of male...

neospora caninum (n. caninum) is an apicomplexan parasite and causes abortion and congenital neosporosis in cattle worldwide. in this study, we evaluate the virulence of a n. caninum isolate on mouse strain c57bl/6. six groups of five mice c57bl/6 were intraperitoneally inoculated with 1 × l07, 1.5 × l07, 2 × l07, 3 × l07 and 4 × l07 tachyzoites and a control inoculum of dmem, respectively. cli...

Introduction. Hepatitis C is a liver disease with high chronicity, the cause of cirrhosis and hepatocarcinoma. The main obstacle to controlling hepatitis lack vaccines.
 aim work was compare immunogenic activity nonstructural recombinant proteins NS3, NS4 NS5B virus (HCV) as components subunit candidate vaccine analyze adjuvant properties two available commercial drugs, polymuramil pyrogen...

Inbred mice were essential animal models for scientific research during the 20th century and will contribute decisive results in the current and next centuries. Far from becoming an obsolete research tool, the generation of new inbred strains is continuing and such strains are being used in many research fields. However, their genetic properties have been overlooked for decades, although recent...

C57BL/6 is a well-characterized mouse strain that is used extensively for immunological and neurological research. The establishment of C57BL/6 ES cell lines has facilitated the study of gene-altered mice in a pure genetic background-however, relatively few such lines exist. Using a defined media supplement, knockout serum replacement (KSR) with knockout DMEM (KSR-KDMEM), we find that we can re...

There is large variation in the survival of inbred mouse strains infected with Trypanosoma rhodesiense (EATRO 1886). Of those strains that survived for at least 22 days postinfection, female mice were markedly more resistant than male mice. The longer a strain survived, the greater was the difference in survival between male and female mice. Parasite counts were higher in male mice than in fema...

Southern blot analysis with a murine interferon-alpha2 (MuIFN-alpha2) cDNA probe revealed restriction fragment polymorphism of EcoRI- and HindIII-digested C57BL/6 and BALB/cDNA. The inheritance pattern of this polymorphism was examined using DNA from each of the seven recombinant inbred strains derived from C57BL/6 and BALB/c; the strain distribution pattern suggests linkage of INF-alpha genes ...

Inbred strains of laboratory mice are commonly used in different immunological studies, with varying results. However, these variations are often overlooked and the underlying molecular mechanisms are less explored. In this study, we analyzed the differences in B-lymphocyte response and mechanisms of class switch recombination in two commonly used mouse strains, FVB and C57BL/6. These two strai...