Abstract Introduction Clinicians prescribing hypnotics remain concerned regarding the inability to discontinue after chronic use, which has never been directly tested in a controlled prospective study using self-administration choice methodology. This reports on difficulty discontinuing medication as function of basal sleep disturbance insomnia subjects instructed stop taking their 6 months nig...

Abstract Background This commentary presents several thoughts elicited by the observation of Lambers et al. (Plant Soil, 2021) in this Special Issue that release carboxylates roots increases manganese (Mn) uptake plants. Manganese is a plant nutrient, but toxic excess. Root cells take up Mn from rhizosphere solution through non-specific transporters, whose activities are regulated elements othe...