Ischaemia-reperfusion injury (IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells (LSEC). Recent evidence suggests that LSEC co-ordinate and regulates the livers response to a variety of injuries. It ...

Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and is characterized by widespread tubular and microvascular damage. The tumor suppressor p53 is upregulated after IRI and contributes to renal injury in part by promoting apoptosis. Acute, short-term inhibition of p53 with pifithrin-alpha conveys significant protection after IRI. The hypoxia-inducible factor-1 (HI...

The ionospheric total electron content (TEC) in the low-latitude Singapore region (geographic latitude 01.37° N, longitude, 103.67° E, geomagnetic latitude 8.5° S) for 2010 to 2011 was retrieved using the data from global positioning system (GPS)-based measurements. The observed TEC from GPS is compared with those derived from the latest International Reference Ionosphere (IRI)-2012 model with ...

introduction: vaccination has been the most effective human intervention in alleviating human sufferings and death. vaccine production in iran has a long history however, in the face of a changing global landscape, it requires a new roadmap for research, development and production in the coming decades. methods: this document was drafted based on article a of the “comprehensive national scienti...

The main purpose of this study was to determine feeding habits of young of the year striped sea bream, Lithognathus mormyrus (Linnaeus, 1758) from Canakkale shallow waters (<2m). With this purpose, stomach contents of 113 specimens, total length from 33 to 125 ± 0.18 mm, collected by beach seine from January to December 2007, from 6 different sampling locations, were analyzed. The overall perce...

This paper presents a new approach to adaptive document binarization, inspired by the attributes of the Human Visual System (HVS). The proposed algorithm combines the characteristics of the OFF ganglion cells of the HVS with the classic Otsu binarization technique. Ganglion cells with four receptive field sizes tuned to different spatial frequencies are employed, which, adopting a new activatio...

BACKGROUND Tissues fibrosis is caused by ischemia-reperfusion injury (IRI) and results in organ dysfunction. In this study, we aimed to investigate whether fibrosis occurs after uterine ischemia-reperfusion injury, and to investigate the effects of puerarin (Pur) on the fibrosis process in rats. MATERIAL AND METHODS Twenty-four female Wistar rats were randomly divided into three groups (8 in ea...

BACKGROUND The effect of paricalcitol on renal ischemia-reperfusion injury (IRI) has not been investigated. We examined whether paricalcitol is effective in preventing inflammation in a mouse model of IRI, and evaluated the cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) pathways as a protective mechanism of paricalcitol. METHODS Paricalcitol (0.3 μg/kg) was administered to male C57BL/6 ...

BACKGROUND Endothelial dysfunction contributes to ischemia-reperfusion injury (IRI) and is reduced by ischemic preconditioning (IPC). IPC may involve activation of ATP-sensitive potassium channels (K(ATP)). We determined whether modulation of K(ATP) channels occurs in endothelial IPC in humans. METHODS AND RESULTS IRI of the forearm was induced by inflating a blood pressure cuff to 200 mm Hg ...