نتایج جستجو برای: in inhibitors

تعداد نتایج: 17008325  

, E Sadeghi, F Noor Mohammadi Far, M Choubsaz , M Payandeh, M Sadeghi, N Amirifard ,

  Background: Hemophilia is the most frequent severe hereditary hemorrhagic disease due to deficiency of coagulation factors VIII (Hemophilia A) or IX (Hemophilia B) in plasma. We aimed to identify patients with  hemophilia in Kermanshah, Iran and assess the incidence of inhibitors in this population and its associated factors. Methods: This study was conducted on patients with hemophilia...

Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and...

Journal: :international journal of advanced biological and biomedical research 2014
masoud karimi goftar narges alizadeh rayeni samira rasouli

objective: in this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. dna topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as dna replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the dna. result...

Journal: :نامه انجمن حشره شناسی ایران 0
m. saber g. nouri ganbalani m. j. hejazi h. rafiee dastjerdi

insect growth regulators and spinosyns which are physiologically and ecologically selective, respectively, have been investigated as replacements or complements to non-selective conventional insecticides. the effects of diflubenzuron, hexaflumuron, profenofos, spinosad and thiodicarb were assessed on the 1st instars of cotton bollworm, helicoverpa armigera (hã¼bner) using dietary and leaf disc ...

Journal: :medical laboratory journal 0
maryam mohajerani faculty of basic sciences, university of mazandaran, babolsar, iran afsane aghaei faculty of basic sciences, university of mazandaran, babolsar, iran

abstract        background and objective: peroxidases catalyze protein oxidation and lipid peroxidation. the activity of these enzymes in nerve cells is involved in causing disorders such as alzheimer's and parkinson's disease. this study investigated the effect of citrus aurantium, foeniculum vulgare and rosmarinus officinalis essential oils on activity of peroxidase enzyme.       me...

Journal: :international journal of hematology-oncology and stem cell research 0
ahmad ahmadzadeh health research institute, research center of thalassemia and hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran elahe khodadi health research institute, research center of thalassemia and hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran mohammad shahjahani health research institute, research center of thalassemia and hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran jessika bertacchini department of surgery, medicine, dentistry and morphology, university of modena and reggio emilia, modena, italy tina vosoughi health research institute, research center of thalassemia and hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran najmaldin saki health research institute, research center of thalassemia and hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran

histone deacetylases (hdacs) are the enzymes causing deacetylation of histone and non-histone substrates. histone deacetylase inhibitors (hdis) are a family of drugs eliminating the effect of hdacs in malignant cells via inhibition of hdacs. due to extensive effects upon gene expression through interference with fusion genes and transcription factors, hdacs cause proliferation and migration of ...

Ghorbanian MT Rahnama A, Zavareh S

Background: The efficiency of in vitro maturation (IVM) has remained low despite extensive effort to understand the culture conditions. This study investigated the effect of cumulus cells and meiotic inhibitors on oocyte developmental competence in the presence of Alpha Lipoic acid (ALA) Materials and Methods: Mouse germinal vesicle oocytes were considered in cumulus-denuded oocytes (CDOs) and ...

Journal: :journal of sciences islamic republic of iran 0

several nonpeptide small molecules were designed as potential inhibitors of hiv protease and their structures were constructed by computer-aided molecular modeling and docked iwo the active site of hiv protease. models of the complexes of inhibitors and the hiv protease were refined using nonbonded and h-bonding terms. the refined energy of selected complexes showed that the designed inhibitors...

Journal: :iranian journal of pharmaceutical sciences 0
mohammad hassan karimfar department of toxicology and pharmacology, pharmaceutical sciences and medicinal plant research centers, faculty of pharmacy, tehran university of medical sciences, tehran, iran college of pharmacy, zabol university of medical sciences, zabol, iran shervin gholizadeh department of toxicology and pharmacology, pharmaceutical sciences and medicinal plant research centers, faculty of pharmacy, tehran university of medical sciences, tehran, iran amir peyman hajrasouliha department of toxicology and pharmacology, pharmaceutical sciences and medicinal plant research centers, faculty of pharmacy, tehran university of medical sciences, tehran, iran abdol hossain miri college of pharmacy, zabol university of medical sciences, zabol, iran kaveh tabrizian department of toxicology and pharmacology, pharmaceutical sciences and medicinal plant research centers, faculty of pharmacy, tehran university of medical sciences, tehran, iran kian azami department of toxicology and pharmacology, pharmaceutical sciences and medicinal plant research centers, faculty of pharmacy, tehran university of medical sciences, tehran, iran mohammad abdollahi

in this study, we investigated the interactive effects of intraperitoneal (i.p.) injections of three different phosphodiesterase inhibitors (pdeis) on morphine-induced analgesia in mice using tail-flick method. subcutaneous administration of morphine (1, 3 and 6 mg/kg) caused significant antinociceptive effects in a dose dependent manner. administration of pentoxifylline (12.5, 25, 50 and 100 m...

Introdution: Lipoxygenase enzyme is responsible for biosynthesis of leukotrienes that possess various pharmacological effects in the body. The beneficial therapeutic effects of lipoxygenase inhibitors have been proved in some diseases such as asthma, cancer and Alzheimer’s disease. So, the lipoxygenase inhibitors could be used in the treatment of some diseases and pathological conditions. In th...

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