Tumors harbor several populations of dendritic cells (DCs) with the ability to prime tumor-specific T cells. However, these T cells mostly fail to differentiate into armed effectors and are unable to control tumor growth. We have previously shown that treatment with immunostimulatory agents at the tumor site can activate antitumor immune responses and is associated with the appearance of a popu...

This work examines the stability and accuracy of four di¤erent methods to estimate Risk-Neutral Density functions (RNDs) using European options. These methods are the Double-Lognormal Function (DLN), the Smoothed Implied Volatility Smile (SML), the Density Functional Based on Con‡uent Hypergeometric function (DFCH) and the Edgeworth expansions (EE). These methodologies were used to obtain the R...

In rats, androgens in adulthood regulate the morphology of motoneurons in the spinal nucleus of the bulbocavernosus (SNB), including the size of their somata and the length of their dendrites. There are conflicting reports about whether androgens exert similar influences on SNB motoneurons in mice. We castrated or sham-operated C57BL6J mice at 90 days of age and, thirty days later, injected cho...

Galectins have emerged as potent immunoregulatory agents that control chronic inflammation through distinct mechanisms. Here, we report that treatment with Galectin-8 (Gal-8), a tandem-repeat member of the galectin family, reduces retinal pathology and prevents photoreceptor cell damage in a murine model of experimental autoimmune uveitis. Gal-8 treatment increased the number of regulatory T ce...

T cell migration toward sites of antigen exposure is mediated by G protein signaling and is a key function in the development of immune responses. Regulators of G protein signaling (RGS) proteins modulate G protein signaling; however, their role in the regulation of adaptive immune responses has not been thoroughly explored. Herein we demonstrated abundant expression of the Gi/Gq-specific RGS3 ...

Immune checkpoint inhibitors (ICIs) can sometimes produce a durable response in melanoma patients. However, the clinical benefits are usually limited. We attempted to elucidate dynamics of tumor infiltrating lymphocytes (TILs) responder; we tracked TILs metastatic tissue during anti-PD-1 therapy obtain clues for maximizing effect ICIs. First, performed single cell RNA and T receptor (TCR) seque...

Abstract Ly-6A is a GPI-anchored cell surface protein with reported adhesion and signaling role in CD4 +T cells. shows low expression on naïve T cells; however, its elevated upon activation. Additionally, IFN-γ IL-27 cytokines increase expression, feature observed immune checkpoint inhibitory (ICI) proteins, such as PD-1 CTLA-4. Many reports using lines primary cells show, for ICI inhibiting cl...

Recall that variation distance is defined as ‖μ− ξ‖ = 12 ∑ x∈Ω |μ(x)− ξ(x)| = maxA⊂Ω |μ(A)− ξ(A)|. Recall also that for any t > τmix · dln −1e we have ∆(t) ≤ . In general, our goal was to randomly sample elements of a large set Ω from a distribution defined implicitly by assigning a positive weight w(x) to each x ∈ Ω and then normalizing. So, Pr[x is choosen] = w(x) Z where Z = ∑ x∈Ω w(x). Howe...

Abstract The accelerated creep behavior during water desorption of wood was modeled on the Kohlausch–Williams–Watts (KWW) function and free volume concept. Assuming that rate dmc/dln t $\text{dmc/dln\,t}$ is involved in creation a new volume, net compliance J du ( t ) obtained...