OBJECTIVES High-intensity interval training (HIIT) increases energy expenditure and mechanical energy efficiency. Although both uncoupling proteins (UCPs) and endothelial nitric oxide synthase (eNOS) affect the mechanical efficiency and antioxidant capacity, their effects are inverse. The aim of this study was to determine whether the alterations of cardiac UCP2, UCP3, and eNOS mRNA expression ...

The transcriptional coactivator PPARγ coactivator-1α (PGC-1α) is a critical regulator of mitochondrial content and function in skeletal muscle. PGC-1α may also mediate mitochondrial adaptations in response to chronic contractile activity (CCA). To characterize the essential role of PGC-1α in organelle biogenesis, C₂C₁₂ murine myotubes were transfected with PGC-1α-specific siRNA and subjected to...

High-intensity interval training (HIIT) has become a promising strategy to induce a number of metabolic adaptations and alter body composition. Recent evidence suggests that HIIT can be a time-efficient strategy to promote health in sedentary overweight/obese individuals. This may be contrary to the belief held by some health professionals that training programs at high intensity are not approp...

BACKGROUND High-intensity interval training (HIIT) improves cardiometabolic markers, but its effects on the quality of life of patients with type 2 diabetes (T2D) is not well known. AIM To determine the effects of a 12-week HIIT exercise program on cardiometabolic and quality of life variables of T2D patients. MATERIAL AND METHODS Nine T2D women were assigned to a HIIT + nutritional educati...

Exercise results in rapid increases in expression of the transcription coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and in mitochondrial biogenesis in skeletal muscle. PGC-1alpha regulates and coordinates mitochondrial biogenesis, and overexpression of PGC-1alpha in muscle cells results in increases in mitochondrial content. In this context, it ha...

Background The idea behind high-intensity interval training (HIIT) is that an individual will burn a greater amount of calories and fat in a shorter period of time than moderate-intensity exercise. While beneficial changes have been seen when HIIT is incorporated into training programs, there is still information about HIIT that is unknown. At moderate intensities, triacylglycerol is the predom...

Soccer is characterized by high aerobic demands interspersed with frequent bursts of anaerobic activity. High-intensity interval training (HIIT) is considered a viable alternative to traditional endurance conditioning and offers the additional time-saving benefits of anaerobic training. We hypothesized that HIIT will compare favorably to traditional (aerobic-based) soccer conditioning over the ...

subject in the following involved, not to say ungrammatical, sentence: " I may add that, as Surgeon to the Evelina Hospital for Children, these deformities of the body have occupied much of my thought and attention, with an earnest desire to erase from the chapter of accidents as many as possible of such unsightly disfigurements; so that in the inevitable struggle for supremacy, in after life, ...

The social force model which belongs to the microscopic pedestrian studies has been considered as the supremacy by many researchers and due to the main feature of reproducing the self-organized phenomena resulted from pedestrian dynamic. The Preferred Force which is a measurement of pedestrian’s motivation to adapt his actual velocity to his desired velocity is an essential term on which the mo...