Introduction Renal transplantation is the therapeutic of choice for the end stage renal disease. With advanced immunosuppressive drug, the outcome of renal transplantation becomes favorable in the present day (1). Tacrolimus is a widely used immunosuppressive drug for post-renal transplantation (2). The concentration of tacrolimus is important for success in management of the patient. The effec...

cladribine acts as an antineoplastic, immunosuppressive and anti-inflammatory agent. the aim of this study was to examine the possible impact of this drug on the epidermis of wistar rats. the control group received standard feed and water. the experimental group i was treated with cladribine in a schema corresponding to the treatment of multiple sclerosis in humans. the material for microscopic...

The polyketide macrolactone FK506 inhibits the growth of Plasmodium falciparum in culture and the enzymatic (peptidyl-prolyl cis-trans isomerase [PPIase]) and chaperone activities of a recently identified P. falciparum FK506-binding protein (PfFKBP35). However, the potent immunosuppressive properties of FK506 exclude it from consideration as an antimalarial drug. We describe the antimalarial ac...

TRANSPLANT A nON has been built on the foundation of using drug thera.py to nonspecifically suppress the recipient immune response. Failure to achieve adequate immunosuppression is associated with a high incidence of graft loss from rejection. The present goal of immunosuppressive regimens is to suppress the immune response to the allograft while preserving sufficient immunity to avoid opportun...

kidney transplantation in children is the treatment of choice to treat end stage renal disease. improvements in immunosuppressive management have dramatically reduced the risk of early acute rejection and graft loss, however the long term results in terms of graft survival and morbidity still require search for new immunosuppressive regimens. reducing of side effects are the challenges for impr...

recent scientific evidence indicates that distinct patterns of susceptibility in balb/c mice to leishmania major infection are attributable to the differential expansion of distinct cd4+ t-cell subsets and their cytokines production. production of the th1 cytokine ifn-g is associated with resistance, whereas production of the th2 cytokines il-4 and il-10 are associated with extreme susceptibili...