this article reviews will focus on the concept and formation of micro particles (mps) in circulation and their role in transfusion medicine and immune system. mps are cell membrane derived vesicles which express markers of their parent cells and are found in circulation at low levels. exact functions of mps are unclear. in here, physiological almost all types of circulating mps including platel...

Abstract The IL-1 family receptor antagonist IL-38 suppresses auto-inflammatory reactions in murine disease models. Given the connection between auto-immunity and anti-tumor immunity, we wondered if targeting would affect latter. transgenic PyMT mammary carcinoma model was employed to target genetically or with a neutralizing antibody. IL-38-deficient (KO) mice had markedly delayed tumor growth...

Induced cell-mediated immunity (hypersensitivity) resulted in selective injury and eradication of premalignant and malignant epidermal lesions in man with minimal or no adverse effects on normal tissues. Immune challenge produced resolu tion of more than 95% premalignant kératoses,superficial basal cell carcinomas, and squamous cell carcinomas in situ in 50 patients without recurrences for obs...

[7] . Though the role of IFN-λ in the context of these conditions has been discussed previously [8–10] , much more research is required to completely understand its physiological and pathological impact. Here, the articles by Koch and Finotto [11] , Griffiths et al. [12] , Stiff and Carson [13] and Mihm [14] aim to shed light on the different functions of IFN-λ. Together, these review articles ...

Essential differences between the innate and acquired branches of immunity are described. These differences concern the detection system (receptors and pathogen structures) and the cells engaged in both systems as well as the effectory mechanisms. In contrast to those of the acquired system, receptors of the innate system, which developed during evolution, recognize unchanged structures on larg...

Relevance. It is known that antitoxic immunity saves from diphtheria, but does not prevent the carriage of Cd (tox+). Asymptomatic carriers (tox+) play a major role in maintaining epidemiological process diphtheria infection. Aims. Characteristics population composition and specifics kinetic reactions (tox-) simultaneously functioning among people. Results. The functional features specific indi...

exposure to high dosages of sulfur mustard (sm) can cause bone marrow depression, immune system suppression, impairment of the immune functions, and eventually results in diseases due to secondary immune disorders. in this article, we have studied the effects of this poison on iranian veterans by analysis of related published studies. in a systematic search, the effects of sm gas on iranian vic...

objective: hypericum perforatum (st. john's wort) has long been used in traditional medicine to treat a variety of internal and external ailments. the present study was done to evaluate the immumodulatory potentials of the hydroalcoholic extract of h. perforatum. materials and methods: twenty male balb/c-mice were randomly allocated in two equal groups and immunized with sheep red blood ce...

Insights into immune reactions against benign and malignant melanocytes may help the development of more efficient immunotherapeutic treatments for melanoma. The interplay between an active systemic antitumor immunity and a responsive local tumor environment is crucial to achieve effective clinical responses. Increasing evidence confirms this strategy can lead to an adequate and durable immunos...

Neonates are particularly susceptible to various pathogens compared to adults, which is attributed in part to their immature innate and adaptive immunity. Natural killer cells provide first-line innate immune reactions against virus-infected cells without prior sensitization. This review updates phenotypic and functional deficiencies of neonatal cells compared to their adult counterparts and th...