BACKGROUND AND PURPOSE The efficacy of radiation therapy, the mainstay of treatment for malignant gliomas, is limited by our inability to accurately determine tumor margins. As a result, despite recent advances, the prognosis remains appalling. Because gliomas preferentially infiltrate along white matter tracks, methods that show white matter disruption should improve this delineation. In this ...

PURPOSE Brain metastases from renal cell carcinoma (RCC) have been successfully treated with stereotactic radiosurgery (SRS). Metastases to extra-cranial sites may be treated with similar success using stereotactic body radiation therapy (SBRT), where image-guidance allows for the delivery of precise high-dose radiation in a few fractions. This paper reports the authors' initial experience with...

In radiation therapy, to deliver continuously a sufficient radiation dose to target volume yields a better therapeutic effect. While, avoiding an exposure to healthy tissues surrounding the target volume is also an important requirement for suppressing the adverse effect. Image-guided radiation therapy (IGRT) has potential to achieve the two requirements and as it’s application, stereotactic bo...

The goal of this work was to develop and evaluate an end-to-end test for determining and verifying image-guided radiation therapy setup accuracy relative to the radiation isocenter. This was done by placing a cube phantom with a central tungsten sphere directly on the treatment table and offset from isocenter either by 5.0 mm in the longitudinal, lateral, and vertical dimensions or by a random ...

Tremendous technological advancements in prostate radiotherapy have decreased treatment toxicity and improved clinical outcomes for men with prostate cancer. While these advances have allowed for significant treatment volume reduction and whole-organ dose escalation, further improvement in prostate radiotherapy has been limited by classic techniques for diagnosis and risk stratification. Develo...

Radiation dose escalation and acceleration improves local control but also increases toxicity. Proton radiation is an emerging therapy for localized cancers that is being sought with increasing frequency by patients. Compared with photon therapy, proton therapy spares more critical structures due to its unique physics. The physical properties of a proton beam make it ideal for clinical applicat...