نتایج جستجو برای: il4
تعداد نتایج: 829 فیلتر نتایج به سال:
The regions encoding the coordinately regulated Th2 cytokines IL5, IL4 and IL13 are located on chromosomes 5 of man and 11 of mouse. They have been intensively studied because these interleukins have protective roles in helminth infections, but may lead to detrimental effects such as allergy, asthma, and fibrosis in lung and liver. We added to previous studies by comparing sequences of syntenic...
Antigen-presenting cells (APC) tailor immune responses to microbial encounters by stimulating differentiation of CD4 T cells into the Th1 and Th2 lineages. We demonstrate that APC use the Notch pathway to instruct T cell differentiation. Strikingly, of the two Notch ligand families, Delta induces Th1, while Jagged induces the alternate Th2 fate. Expression of these different Notch ligands on AP...
The aim of this study was to investigate the T lymphocyte subsets involved in experimental autoimmune uveoretinitis (EAU) by quantifying the numbers of cells expressing mRNA for each of the lymphokines interferon gamma, interleukin 2, interleukin 4, and lymphotoxin throughout the disease process. Lewis rats were immunised with retinal S-antigen to provide a model of inflammatory eye disease. In...
مقدمه: فعالیت ورزشی نقش مؤثری در تغییر عوامل مؤثر در سرطان دارد، اما تأثیر فعالیت بدنی بر سطوح عوامل مؤثر سرطان در انسان یا حیوانات مبتلا به آن، تا به حال مورد توجه جدی قرار نگرفته است. پژوهش حاضر به بررسی تأثیر فعالیت ورزشی استقامتی پیوسته بر میزان حجم تومور در موش های مبتلا به سرطان سینه می پردازد. مواد و روش ها: در این مطالعه تعداد 30 سر موش بالب سی ماده (4 تا 5 هفته ای با میانگین وزنی 76/17...
Abstract Background and purpose: IL22 is the family member of IL10 created by Th17, Th22, NK cells and its role has been recently demonstrated in protection and innate defense mechanisms, control of bacterial and viral infection, homeostasis and tissue repair. This research investigated the impacts of Il22 treatment on lesion originated from L-major in BALB/c mice. Materials and methods: Tw...
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