نتایج جستجو برای: il2ra
تعداد نتایج: 257 فیلتر نتایج به سال:
The genetic basis of autoantibody production is largely unknown outside of associations located in the major histocompatibility complex (MHC) human leukocyte antigen (HLA) region. The aim of this study is the discovery of new genetic associations with autoantibody positivity using genome-wide association scan single nucleotide polymorphism (SNP) data in type 1 diabetes (T1D) patients with autoa...
Sarcoidosis, a systemic granulomatous syndrome invariably affecting the lung, typically spontaneously remits but in ~20% of cases progresses with severe lung dysfunction or cardiac and neurologic involvement (complicated sarcoidosis). Unfortunately, current biomarkers fail to distinguish patients with remitting (uncomplicated) sarcoidosis from other fibrotic lung disorders, and fail to identify...
Multiple sclerosis is a chronic autoimmune demyelinating disease of the central nervous system, which is thought to be triggered by environmental factors in genetically susceptible individuals leading to activation of autoreactive T lymphocytes. Large multi-centre genome-wide association studies have identified multiple genetic risk loci in multiple sclerosis. In this study, we investigated T c...
Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV1). The activation of NFB by Tax has been reported to play a crucial role in HTLV-1–induced transformation. The HTLV-1 bZIP factor (HBZ), which is encoded by an mRNA of the opposite polarity of the viral genomic RNA, is involved in both T cell proliferation and suppression of T...
Abstract Th17-cells play a key role in the pathogenesis of autoimmune hepatitis (AIH), severe hepatopathy characterized by hypergammaglobulinemia, seropositivity for autoantibodies and interface on histology. Aberrant Th17-cell response AIH is linked to alterations aryl-hydrocarbon-receptor (AHR) signaling. These result inability respond AHR activation. Since can be regulated upon binding aryl-...
Abstract Background The single nucleotide polymorphism (SNP) rs61839660 lies within the IL2RA (CD25) intronic enhancer and has been identified as a causal variant in Crohn’s disease (CD), with heterozygote frequency of 16.8% European population. CD25 is high-affinity receptor for IL-2, constitutively expressed on regulatory T cells (Tregs). Low-dose IL-2 (LD-IL2) under investigation IBD, premis...
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