نتایج جستجو برای: il18
تعداد نتایج: 258 فیلتر نتایج به سال:
Neutrophils are an abundant immune cell type involved in both antimicrobial defence and autoimmunity. The regulation of their gene expression, however, is still largely unknown. Here we report an eQTL study on isolated neutrophils from 114 healthy individuals of Chinese ethnicity, identifying 21,210 eQTLs on 832 unique genes. Unsupervised clustering analysis of these eQTLs confirms their role i...
The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease, ulcerative colitis. Here, we show that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis. Deletion of Il18 or its receptor Il18r1 in intestinal ep...
Hypothesis / aims of study There is increasing evidence showing that prostatic inflammation is associated with the development of histological benign prostatic hyperplasia (BPH) and male lower urinary tract symptoms (LUTS) [1]. It has also been reported that dutasteride, which inhibits 5α-reductase, might have anti-inflammatory effects in the prostate of patients with lower urinary tract sympto...
Rachel Nadif, Margaret Mintz, Jacqui Marzec, Anne Jedlicka, Francine Kauffmann, Steven R. Kleeberger, 1 INSERM U780, Villejuif, France 2 Université Paris Sud, Faculté de médecine, IFR69, Villejuif, France 3 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD USA 4 Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Par...
The article by Tano and Gollasch published in Frontiers in Physiology reviewed the involvement of Ca-sensitive K channels in ischemia and reperfusion, with cardio-vascular and brain models mostly discussed (1), where the increased Na inflow activates Na–Ca exchanger, and leads to cell membrane depolarization (2). Activated Na–Ca exchanger works to pump Na out and Ca in (2). The increase in intr...
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