Methods 17 pCD patients with granulomas were genotyped for CD-associated mutations or polymorphisms in NOD2 and autophagy-related genes ATG1 and ATG16L1. Granulomas were found in intestinal biopsies of 22 out of 83 endoscopic and 9 out of 12 surgical procedures. Of each procedure we selected one biopsy per organ to study the cellular composition and cytokine profile of granulomas. We stained 43...

Chronic venous leg ulcers cause significant morbidity in patients and the majority reoccur after resolution. The current standard of care, double layer compression, is not effective all patients. Interleukin 17A (IL17) antagonist therapy has been shown to promote healing murine models chronic wounds. This previously explored humans. Therefore, we aim undertake a phase II randomized, double-blin...

Abstract Summary: Accumulating evidence supports the impact of gut microbiota on clinical efficacy cancer immunotherapies against extraintestinal tumors, but it has not yet been addressed whether local commensals could also dictate prognosis patients with cancer. In this issue Cancer Discovery, Tsay and colleagues demonstrate that lower airway may harbor oral turn IL17-mediated inflammatory pat...

Background and aimAlthough studies have associated elevated prenatal obesity with increased risk of various diseases in offspring, little is known regarding the immune system. The aim this study was to evaluate relationship between levels cytokines umbilical cord blood development allergic disease during first 10 years life an offspring.MethodsA cohort term infants born at ShaoXing Women Childr...

Background Although it prevents severe forms of the disease, vaccination does not completely protect against occurrence COVID19 disease. If, DMARDs used have been associated with variable humoral response to SARS-CoV-2 vaccination, impact their use after natural infection poorly studied. Objectives To characterize and viral persistence in nasopharyngeal sphere (NP), stools blood patients rheuma...