il 33

Jürgen Pollheimer Johanna Bodin Olav Sundnes Reidunn J Edelmann Sigrid S Skånland Jon Sponheim Mari Johanna Brox Eirik Sundlisaeter Tamara Loos Morten Vatn Monika Kasprzycka Junbai Wang Axel M Küchler Kjetil Taskén Guttorm Haraldsen Johanna Hol

OBJECTIVE Interleukin (IL)-33 is a nuclear protein that is released from stressed or damaged cells to act as an alarmin. We investigated the effects of IL-33 on endothelial cells, using the prototype IL-1 family member, IL-1β, as a reference. METHODS AND RESULTS Human umbilical vein endothelial cells were stimulated with IL-33 or IL-1β, showing highly similar phosphorylation of signaling mole...

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Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells

2016

Carl D Richards Laura Izakelian Anisha Dubey Grace Zhang Steven Wong Karen Kwofie Aatif Qureshi Fernando Botelho

IL-33 modulates both innate and adaptive immune responses at tissue sites including lung and may play critical roles in inflammatory lung disease. Although IL-33 expression can be altered upon NF-Kappa B activation, here we examine regulation by Oncostatin M, a gp130 cytokine family member, in mouse lung tissue. Responses were assessed in BALB/c mouse lung at day 7 of transient overexpression u...

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Quantitative phosphoproteomic analysis of IL-33-mediated signaling

Journal: :PROTEOMICS 2015

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IL-33-HIF1α Axis in Hypoxic Pulmonary Hypertension

Journal: :EBioMedicine 2018

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The Role of IL-33 in Rheumatic Diseases

Journal: :Clinical and Developmental Immunology 2013

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