نتایج جستجو برای: il 15
تعداد نتایج: 627023 فیلتر نتایج به سال:
IL-15 is an important cytokine for the function of the immune system, but the form(s) of IL-15 produced in the human body are not fully characterized. Coexpression of the single-chain IL-15 and the IL-15 receptor alpha (IL-15Rα) in the same cell allows for efficient production, surface display, and eventual cleavage and secretion of the bioactive IL-15/IL-15Rα heterodimer in vivo, whereas the s...
Since its discovery in 1994, IL-15 has been studied in the context of its structural cousin, IL-2 (1). Early biochemical and in vitro lymphocyte studies revealed many similarities between IL-15 and IL-2: (a) IL-2 and IL-15 constitute the only two members of a family of cytokines containing a four a helix bundle; (b) the heterotrimeric receptors for IL-2 and IL-15 share both the IL-2/15R b and I...
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