This research is an experimental study through elaborates the Active Knowledge Sharing (AKS) learning model to improve students' High Order Thinking Skills (HOTS). The low ability of students analyze, evaluate, and create due lack application questions that deliver solve problems contain HOTS. four stages in AKS will serve as a reference for students’ HOTS integrated 4Cs. sample was student Che...

Ornithine decarboxylase (ODC) is a ubiquitous enzyme that is conserved in all species from bacteria to humans. Mammalian ODC is degraded by the proteasome in a ubiquitin-independent manner by direct binding to the antizyme (AZ). In contrast, Trypanosoma brucei ODC has a low binding affinity toward AZ. In this study, we identified key amino acid residues that govern the differential AZ binding a...

Carac (5-fluorouracil 0.5% cream, Aventis Pharma) was approved by the US FDA in October 2000, for the treatment of multiple actinic or solar keratoses involving the face and anterior scalp. The cream should be applied in a thin film once daily to the skin where actinic keratoses (AKs) are present. When it is applied for 1, 2, or 4 weeks, it is significantly more effective than a vehicle in the ...

Non-melanoma skin cancer (NMSC) is traditionally treated with surgical excision. Nonsurgical methods such as cryotherapy and topical chemotherapeutics, amongst other treatments, are other options. Actinic keratosis (AKs) are considered precancerous lesions that eventually may progress to squamous cell carcinoma (SCC). Photodynamic therapy (PDT) offers an effective treatment for AKs, and is also...

To directly evaluate the role of increased ornithine decarboxylase (ODC) and polyamines in mouse skin carcinogenesis, we used bovine keratin 5 (K5) and keratin 6 (K6) promoter elements to direct the expression of antizyme (AZ) to specific skin cell populations. AZ is a multifunctional regulator of polyamine metabolism that inhibits ODC activity, stimulates ODC degradation, and suppresses polyam...

The oil palm (Elaeis guineensis Jacq.) fruit primary abscission zone (AZ) is a multi-cell layered boundary region between the pedicel (P) and mesocarp (M) tissues. To examine the cellular processes that occur during the development and function of the AZ cell layers, we employed multiple histological and immunohistochemical methods combined with confocal, electron and Fourier-transform infrared...

Actinic keratoses (AKs) are common premalignant skin lesions. Population-based research on AKs is limited, however. Anecdotally, many patients with have new at future visits, but evidence for this lacking. We aimed to evaluate the number and timing of repeated occurrences in individual patients. performed a retrospective cohort study using Medicare dataset 4,999,999 aged ≥65 from 2009 2018. inc...

Zusammenfassung Aktinische Keratosen (AKs) sind definiert als intraepidermale Proliferation atypischer Keratinozyten auf UV-geschädigter Haut mit dem Potenzial, in ein invasives kutanes Plattenepithelkarzinom (PEK) fortzuschreiten. AKs zählen zu den häufigsten Dermatosen im dermatologischen Alltag hoher Morbidität insbesondere bei älteren oder immunsupprimierten Patienten. Eine frühe und konseq...

Bacterial redox protein azurin (azurin for short, or Az) belongs to a class of copper-containing proteins known as cupredoxins. We report here our detailed studies and findings on prospects for application of Az for treatment of cancer through various approaches of nanotechnology. We first present the structure and characteristics of Az protein molecule, its electronic properties and its electr...

Algorithms of the new “cyclotomic AKS class” determine rigorously and in polynomial time whether an input integer is prime. Herein are discussed implementation issues, with a focus on techniques such as asymptotically fast polynomial manipulations, the possible use of floating-point arithmetic, and special powering ladders. We implemented various of the ideas herein on an Apple G4, Mac OS X sys...