BACKGROUND: Immunoglobulin-G (IgG) is a product of the initial response to secondary immune response, which accumulates in distal segment nerve after crush injury. Thymoquinone modulates adaptive response. Effect thymoquinone administration on local IgG levels Rattus norvegicus Wistar rats sciatic injury model has not been elucidated.METHODS: This was an experimental study, with 63 that divided...

Background and Purpose: Although molds are regarded as the main fungal allergen sources, evidence indicates that spores of Basidiomycota including Agaricus bisporus (A. bisporus) can be also found at high concentrations in the environment and may cause as many respiratory allergies as molds. The aim of the present study was to evaluate specific immunoglobulin E (IgE) and immunoglobulin G (IgG) ...

Abstract To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting total 1,782 plasma samples from 869 donors Wuhan, China and test specific antibody responses. The results show that positive rate IgG against receptor-binding domain spike protein (RBD-IgG) to severe acute respi...

Signaling by transmembrane immunoglobulin G (IgG)–Fc receptors (Fc Rs) in response to ligand involves association with membrane microdomains that contain glycosyl phosphatidylinositol (GPI)– anchored proteins. Recent in vitro studies showed enhancement of Fc R signaling by forced monoclonal antibody– mediated cocrosslinking with various GPIanchored proteins. Here, the possibility that GPI-ancho...

The relative lack of memory for IgG antipolysaccharide responses is believed to be secondary to the inability of polysaccharides to associate with MHC class II molecules and thus a failure to recruit cognate CD4+ T cell help. However, little is known concerning the role of T cells and the generation of memory for antipolysaccharide Ig responses to intact extracellular bacteria. We used heat-kil...

The capacity of interferon-gamma to regulate the generation and release of leukotriene B4 (LTB4) from human alveolar macrophages ofnormal nonsmoking individuals was evaluated. When alveolar macrophages were incubated for 60 min with heat aggregated IgG (HAIgG), they generated and released 5.7±1.7 ng ofLT B4 per 106 cells compared to 1.9±0.4 ng from cells incubated with buffer alone, P = 0.02. W...

We determined whether primed and unprimed B cells in the spleen of (BALB/c x C57BL/Ka)F(1) mice contain subpopulations that express a predominant surface Ig isotype. Spleen cells were stained for surface isotypes and sorted on the fluorescence-activated cell sorter (FACS) in order to obtain B cells bearing predominantly IgM (mup cells), IgD (deltap cells), or IgG (gammap cells). Each population...

Schizophrenia is a complex brain disorder that may be accompanied by idiopathic inflammation. Classic central nervous system (CNS) inflammatory disorders such as viral encephalitis or multiple sclerosis can be characterized by incongruent serum and cerebrospinal fluid (CSF) IgG due in part to localized intrathecal synthesis of antibodies. The dietary antigens, wheat gluten and bovine milk casei...

Recent reports indicate that transforming growth factor alpha (TGF-alpha) is produced within the liver and acts as the natural ligand of the epidermal growth factor (EGF) receptor causing the EGF receptor down regulation and the hepatocyte proliferation observed after partial hepatectomy. The reported phenomenon that an antibody to EGF inhibits the regenerative response to partial hepatectomy w...