نتایج جستجو برای: ifn β
تعداد نتایج: 211090 فیلتر نتایج به سال:
Interferon (IFN)-λ forms the type III IFN family. Although they signal through distinct receptors, type I (IFN-α/β) and type III IFNs elicit remarkably similar responses in cells. However, in vivo, type III and type I IFN responses are not fully redundant as their respective contribution to the antiviral defense highly depends on virus species. IFN-λ is much more potent than IFN-α/β at controll...
The family of type I interferons (IFN), which consists of several IFN-α and one IFN-β, are produced not only after stimulation by viruses, but also after infection with non-viral pathogens. In the course of bacterial infections, these cytokines could be beneficial or detrimental. IFN-β is the primary member of type I IFN that initiates a cascade of IFN-α production. Here we addressed the questi...
IFN-α/β was first described as a potent inhibitor of viral replication, but it is now appreciated that IFN signaling plays a pleiotropic role in regulating peripheral T cell functions. Recently, IFN-α/β was shown to block human Th2 development by suppressing the transcription factor GATA3. This effect is consistent with the role for IFN-α/β in suppressing allergic inflammatory processes by bloc...
Type I interferons (IFN-α /β) were originally identified as humoral factors, which are secreted in virally infected cells and confer an antiviral state in uninfected cells. Subsequently, their multifunctional roles have also been demonstrated, which include antitumor actions. More recently, the IFN system has been the focus of much attention in the context of the regulation of the innate and ad...
Dendritic cells (DCs), especially plasmacytoid DCs (pDCs), produce large amounts of alpha/beta interferon (IFN-α/β) upon infection with DNA or RNA viruses, which has impacts on the physiopathology of the viral infections and on the quality of the adaptive immunity. However, little is known about the IFN-α/β production by DCs during infections by double-stranded RNA (dsRNA) viruses. We present h...
Pharmacological stimulation of the antiviral cytokine IFN-β in the airways may help to counter deleterious virus-induced exacerbations in chronic inflammatory lung diseases (asthma, chronic obstructive pulmonary disease, or cystic fibrosis). Polyinosinic-polycytidylic acid [poly(I:C)] is a known inducer of IFN-β but also costimulates an inflammatory response. The latter response is undesirable ...
BACKGROUND Experimental autoimmune uveoretinitis (EAU) serves as a model for human intraocular inflammation. IFN-β has been used in the treatment of certain autoimmune diseases. Earlier studies showed that it ameliorated EAU; however, the mechanisms involved in this inhibition are still largely unknown. METHODOLOGY/PRINCIPAL FINDINGS B10RIII mice were immunized with interphotoreceptor retinoi...
سایتوکاین‌ها نقش مهمی در بروز بیماری MS دارند و هدف مهمی برای مداخلات درمانی به‌شمار می‌روند. هدف این مطالعه بررسی اثر تمرینات پیلاتس همراه با ماساژدرمانی بر سطوح سرمی سایتوکاین‌های IL-17 و IFN-β در زنان مبتلا به MS است. در این مطالعه از نوع کارآزمایی بالینی از میان بیماران زن دارای پرونده در انجمن MS شهرستان تبریز، تعداد 36 نفر به‌عنوان نمونه با درجة بیماری 0 تا 5/4، میانگین مدت بیماری 2±7 سال...
IFN-β, IL-27, and IL-10 have been shown to exert a range of similar immunoregulatory effects in murine and human experimental systems, particularly in Th1- and Th17-mediated models of autoimmune inflammatory disease. In this study we sought to translate some of our previous findings in murine systems to human in vitro models and delineate the interdependence of these different cytokines in thei...
Adult T-cell Leukemia/Lymphoma (ATLL) is an aggressive T-cell malignancy with a poorly understood pathology that manifests from human T-lymphotropic virus type I (HTLV-1) infected T-cells, typically after long latency periods (430 years). Current treatment regimens for ATLL include zidovudine (AZT) and interferon alpha (IFN-α) combination therapy. The established usage of IFN-α in the treatment...
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