Partial deletions of the gene encoding the neuronal splicing regulator RBFOX1 have been reported in a range of neurodevelopmental diseases, including idiopathic generalized epilepsy. The RBFOX1 protein and its homologues (RBFOX2 and RBFOX3) regulate alternative splicing of many neuronal transcripts involved in the homeostatic control of neuronal excitability. In this study, we explored if struc...

conclusions it became clear at the end of the study that the effectiveness of two drugs were the same and they didn’t have any meaningful difference. according to the result gained from this study, levetiracetam is a proper alternative treatment instead of sodium valproate which has appropriate effectiveness along with lower complications. results comparison of mean generalized tonic colonic at...

This article reviews the ictal and interictal EEG findings associated with a select group of generalized seizures. These include absence seizures, myoclonic seizures seen in juvenile myoclonic epilepsy, idiopathic generalized tonic clonic seizures, infantile spasms, and atypical absence, tonic, and atonic seizures associated with the Lennox Gastaut syndrome.

BACKROUND Epilepsy has a complex etiology characterised by recurring seizures. PURPOSE To study clinical profile of epilepsy patients with reference to type of epilepsy in northwest India. No previous Indian study has reported relative incidence of various types of seizures with reference to type of epilepsy. METHODS Data of 400 epilepsy patients (200 idiopathic and 200 symptomatic) was col...

Rosenow (1947b) has reported the isolation of an immunologically identifiable strain of alpha streptococcus from patients with idiopathic epilepsy. He also reports that the intradermal injection of antibodies specific for this strain elicits an erythematous skin reaction in patients harbouring this organism, and in a high percentage of other epileptic patients as well. This paper presents an in...

OBJECTIVE To delineate the temporal patterns of outcome and to determine the probability of seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy. METHODS Patients in whom epilepsy was diagnosed and the first antiepileptic drug prescribed between July 1, 1982, and April 1, 2006, were followed up until March 31, 2008. Outcomes were categorized into 4 patterns:...

\s=b\There has never been a single set of criteria for the ascription of disease. The pathoanatomic view ascribed to Virchow and propounded by Thomas Szasz has coexisted with the patientcentered or phenomenologic view for millenia. Schizophrenia, as well as such entities as idiopathic epilepsy and migraine, may be considered a disease because it entails suffering and incapacity, albeit in the a...

Children with epilepsy are known to be prone to educational underachievement as a result of learning and behavioural problems. Identification of these comorbidities and their early intervention will go a long way in improving quality of life of children with epilepsy. The objective of this paper is to study the incidence of behavioural disorders (BD) and school underachievement (SU) in newly di...

Background: In 2017, the international league against epilepsy (ILAE) classification of epilepsies described “genetic generalized epilepsies”, which contained “idiopathic epilepsies”. This study delineates four syndromes comprising IGEs: childhood absence epilepsy, juvenile myoclonic (JME), and with tonic-clonic seizures alone (GTCA). JME patients usually present seizures, GTCA GTCS only after ...