Purpose. To determine growth factor levels in individual vitrectomy samples from insulin-d ependent and non-insulin dependent diabetics (IDDM & NIDDM) and to correlate such levels with a) the type of diabetes and b) neovascular activity. Me&m! Over 70 vitreous gel samples wem obtained from diabetic patients with proliferative retinopathy and non-diabetic (“control”) patients undergoing vitrecto...

Nonobese diabetic (NOD) mice genetically deficient in B lymphocytes (NODJg mu(null)) are resistant to T cell-mediated autoimmune insulin-dependent diabetes mellitus (IDDM). Ig infusions from diabetic NOD donors did not abrogate IDDM resistance in NODJg mu(null) mice. However, T cell responses to the candidate pancreatic beta cell autoantigen glutamic acid decarboxylase (GAD), but not the contro...

During the calendar year of 1988 a survey of new cases of insulin dependent diabetes mellitus (IDDM) in children under the age of 15 years in the British Isles was conducted. After cases had been confirmed and permission obtained to contact the families, postal questionnaires were sent to the parents of children diagnosed in England, Wales, Northern Ireland, and the Republic of Ireland. Childre...

Purpose. To determine growth factor levels in individual vitrectomy samples from insulin-d ependent and non-insulin dependent diabetics (IDDM & NIDDM) and to correlate such levels with a) the type of diabetes and b) neovascular activity. Me&m! Over 70 vitreous gel samples wem obtained from diabetic patients with proliferative retinopathy and non-diabetic (“control”) patients undergoing vitrecto...

Defects in IL-4-producing CD1d-autoreactive NKT cells have been implicated in numerous Th1-mediated autoimmune diseases, including diabetes, multiple sclerosis, rheumatoid arthritis, lupus, and systemic sclerosis. Particular attention has been focused on autoimmune insulin-dependent diabetes mellitus (IDDM) because nonobese diabetic (NOD) mice and humans with IDDM are both reported to express s...

The effects of pregnancy and type 1 diabetes [insulin-dependent diabetes mellitus (IDDM)] on protein metabolism are still uncertain. Therefore, six normal and five IDDM women were studied during and after pregnancy, using [(13)C]leucine and [(2)H(5)]phenylalanine with a hyperinsulinemic-euglycemic clamp and amino acid infusion. Fasting total plasma amino acids were lower in pregnancy in normal ...

Target antigens defined by autoantibodies in IDDM include insulin, a putative glycolipid that reacts with islet cell antibodies, and a 64,000-M(r) protein recently identified as glutamic acid decarboxylase. In addition, some IDDM sera that contain antibodies to glutamic acid decarboxylase also coprecipitate a 38,000-M(r) protein from islets. This study used a high titer anti-38,000-M(r) serum t...

In IDDM an association between diabetic retinopathy and polymorphic markers of MHC has been described. However, these associations are complicated by a primary association between the MHC and IDDM. Because the pathogenesis of retinopathy is likely to be the same in IDDM and NIDDM, NIDDM subjects with retinopathy would be the ideal population to study for an association with MHC markers. The fol...

ies incidence that is higher, lower, or similar to that of nondiabetic children. This contradiction may possibly be explained by cohort characteristics, degree of diabetes control, and degree of adherence to dietary prescriptions. Adult patients with poor control of their IDDM seem to have more coronal caries. In the general population, the frequency of root caries increases with age and is thr...

To determine the mechanism of impaired insulin-stimulated muscle glycogen metabolism in patients with poorly controlled insulin-dependent diabetes mellitus (IDDM), we used 13C-NMR spectroscopy to monitor the peak intensity of the C1 resonance of the glucosyl units in muscle glycogen during a 6-h hyperglycemic-hyperinsulinemic clamp using [1-(13)C]glucose-enriched infusate followed by nonenriche...