The use of ICP-MS to measure metal ion content in biological tissues offers a highly sensitive means to study metal-dependent physiological processes. Here we describe the application of ICP-MS to measure membrane transport of Rb and K ions by the Na,K-ATPase in mouse skeletal muscles and human red blood cells. The ICP-MS method provides greater precision and statistical power than possible wit...

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has become established as a very efficient and sensitive trace, ultratrace, and surface analytical technique in the life sciences. We have developed a new analytical imaging technique using LA-ICP-MS to study element distribution in biological tissues. Nowadays, imaging LA-ICPMS using double-focusing sector field (LA-ICP-SF...

This study presents rock slab and thin section reflection mapping, element mapping by Micro-XRF (μ-XRF) analysis, in situ cassiterite U-Pb laser ablation-inductively coupled plasma mass spectrometer (LA-ICP-MS) ages of the Xinlu Sn-Zn deposit, Nanling Sn-W belt, South China. The new results provided constraints on age processes Sn mineralization thus further discussed role Paleo-Pacific plate f...

Organophosphorus pesticides are the most widely used pesticides in modern agricultural systems to ensure good harvests. Isocarbophos (ICP), with a potent acetylcholinesterase inhibitory effect is widely utilized to control a variety of leaf-eating and soil insects. However, the characteristics of the bioactivation and detoxification of ICP in humans remain unclear. In this study, the oxidative ...

Analysis of pharmaceuticals and biomolecules using HPLC coupled to ICPMS and ESI-MS Andrew James Cartwright The work described within this thesis explores the use of HPLC coupled with ICPMS and ESI-MS in order to develop novel methods which overcome specific analytical challenges in the pharmaceutical industry. A membrane desolvation interface has been evaluated for coupling high performance li...

We demonstrated the complementary use of inductively coupled plasma-mass spectrometry (ICP-MS) and electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Q-TOF-MS) for the analysis of Se-containing compounds, such as selenate, selenomethionine (SeMet), and trimethylselenonium ion (TMSe), found in biological samples. The sensitivity of ESI-Q-TOF-MS for Se-containing compounds w...

Cerium dioxide (CeO2) nanoparticles have found wide use in industrial and commercial products, such as coating materials, fuel additives, and nanomedicine, to name a few. As such, it is expected that CeO2 nanoparticles (NPs) will find their way into the environment and may be transported via aqueous systems where they may end up in drinking water and/or plants, both of which increase the possib...

In this study, we evaluated hydrodynamic chromatography (HDC) coupled with inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of nanoparticles in environmental samples. Using two commercially available columns (Polymer Labs-PDSA type 1 and 2), a set of well characterised calibrants and a new external time marking method, we showed that flow rate and eluent composition have f...

Analytical chemistry of metal complexes with biomacromolecules based on the coupling of a high resolution separation technique with an element or species selective detection technique is critically discussed. The role of size-exclusion chromatography (SEC) with on-line atomic spectrometric detection is evaluated for the characterization of the metal distribution among the fractions of different...

In this study, the hyphenation of gas chromatography with ICP tandem mass spectrometry (GC-ICP-MS/MS) for analysis volatile organochlorides in complex hydrocarbon samples is described.