Nanotechnology is an emerging and rapidly growing field whose dynamics and prospects pose many great challenges to scientists and engineers. Nanoparticles are being used in many materials and products, including coatings (on plastic, glass and clothing), sunscreen, antimicrobial bandages and clothing, MRI contrast agents, biomedical elemental tags and fuel additives, only to name few. However, ...

Supplemental Figures: Figure S1. Optimization of fixation and coating conditions for metal imaging. Figure S2. Standard curves for matrix-matched standards for copper LA-ICP-MS and nanoSIMS. Figure S3. Zinc analysis of Calgw71 and WT embryos by LA-ICP-MS. Figure S4. Standard curves for matrix-matched standards for zinc LA-ICP-MS and quantification of zinc images. Figure S5. Selection of regions...

In theory, state of the art inductively coupled plasma mass spectrometry (ICP-MS) instrumentation has the prerequisite sensitivity to carry out multi-elemental trace analyses at sub-ng L-1 to sub-pg L-1 levels in solution. In practice, constraints mainly imposed by various sources of contamination in the laboratory and the instrument itself, and the need to dilute sample solutions prior to anal...

Determination of the radionuclide iodine 129 using ICP-MS has been improved by the use of an Octopole Reaction System (ORS) ICP-MS, operated in oxygen cell mode. Oxygen reaction gas removes the background signal at m/z 129, which is due to the presence of Xe as an impurity in the Ar plasma gas and to the polyatomic ion IH2. NIST SRM standards with different 129I/127I ratios and at multiple conc...

New analytical techniques for multiparametric characterisation of individual cells are likely to reveal important information about the heterogeneity of immunological responses at the single-cell level. In this proof-of-principle study, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was applied to the problem of concurrently detecting 24 lineage and activation markers e...

.................................... ............................................................. vi CHAPTER 1. GENERAL INTRODUCTION ...................................................... 1 The History of Elemental Analysis ...................................................................... 1 ICP-MS ...............................................................................................

The aim of the study is to better understand where uranium deposits in mice kidneys. The spatial distribution of uranium was examined in the kidneys of C57BL/6 mice using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Mice were exposed to varying levels of uranyl nitrate in their drinking water. Calibration standards were developed to allow for semi-quantitative measur...

The Agilent 7500c Inductively Coupled Plasma Mass Spectrometer (ICP-MS) was used for the fast, routine, and reliable analysis of 23 trace elements in urine. The complete method validation for all elements is described, including the evaluation of short-term and long-term stability, the analysis of different reference materials and the discussion of precision and accuracy in internal and externa...

Since the fi rst generation of commercial ICP-MS appeared on the market in the 1980’s, the technique has been adopted for trace elemental analysis across a wide range of industries and applications. The measurement of high matrix samples typical of environmental, clinical, food, nuclear and geological applications, however, remains challenging. When high total dissolved solids (TDS) samples are...