In the reaction of the anticancer drug cis-diamminedichloroplatinum(II) (cis-DDP) with DNA, bifunctional intrastrand and interstrand cross-links are formed. In this work, we show that at 37 degrees C interstrand cross-links (ICL) are labile and rearrange into intrastrand cross-links. The ICL instability was first studied with a 10 base pairs (bp) double-stranded oligonucleotide containing a uni...

PURPOSE An earlier study showed that age-related changes in the inner collagen layer (ICL) inhibit RPE cell repopulation of human Bruch's membrane. The present study was undertaken to determine the effect of cleaning and/or an extracellular matrix (ECM) protein coating on the reattachment, apoptosis, proliferation, and final surface coverage of the transplanted RPE cells. METHODS Explants of ...

The production of riboflavin from vegetable oil was increased using a mutant strain of Ashbya gossypii. This mutant was generated by treating the wild-type strain with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Riboflavin production was 10-fold higher in the mutant compared to the wild-type strain. The specific intracellular catalase activity after 3 d of culture was 6-fold higher in the muta...

BILOG is the defacto standard for dichotomous IRT model estimation. However, BILOG is a commercial product and limited in other ways. Hanson provides an open-source alternative, ICL, and this paper compares ICL to BILOG in terms of features and obtained item parameter estimates. In general, BILOG has more features, especially with respect to assessing model-data fit. One notable feature of ICL ...

BACKGROUND Intradiscal cement leakage (ICL) is a common complication following percutaneous vertebroplasty (PVP). However, the risk factors for such a complication are under debate and there is no accurate predictive nomogram to predict ICL. OBJECTIVES To establish an effective and novel nomogram for ICL following PVP in patients with osteoporotic-related vertebral compression fractures (OVCF...

Not all the light in galaxy groups and clusters comes from stars that are bound to galaxies. A significant fraction of it constitutes so-called intracluster or diffuse (ICL), a low surface brightness component groups/clusters generally found surroundings brightest cluster galaxies intermediate/massive satellites. In this review, I will describe mechanisms responsible for its formation evolution...

We have measured the flux, profile, color, and substructure in the diffuse intracluster light (ICL) in a sample of ten galaxy clusters with a range of mass, morphology, redshift, and density. Deep, widefield observations for this project were made in two bands at the one meter Swope and 2.5 meter du Pont telescope at Las Campanas Observatory. Careful attention in reduction and analysis was paid...

INTRODUCTION When diagnosing Pneumocystis jirovecii pneumonia (PJP), the clinical suspicion must be confirmed by laboratory tests. PJP is rarely described in patients with idiopathic CD4+ lymphocytopenia (ICL), a rare T-cell deficiency of unknown origin with persistently low levels of CD4+ T-cells (<300 µl-1 or <20 % of total lymphocytes) but repeated negative human immunodeficiency virus (HIV)...

Purpose: To evaluate correlations between preoperative sizing of Implantable Collamer Lens (ICL) by white-towhite and sulcus-to-sulcus techniques, and postoperative vault size measured by Sheimpflug imaging. Setting: Persian Eye Clinic, a private eye clinic located in Isfahan city, Iran Design: Prospective, nonrandomized clinical trial Methods: This prospective clinical trial included 63 eyes o...