BACKGROUND Retinoic acid-inducible gene-I (RIG-I) is a putative RNA helicase involved in immune reactions against RNA viruses and various inflammatory and autoimmune diseases. The purpose of the present study was to investigate the role of RIG-I in glomerular diseases. METHODS We treated human mesangial cells in culture with polyinosinic-polycytidylic acid (poly IC), which is an authentic dou...

BACKGROUND Cryptosporidium parvum causes an opportunistic infection in AIDS patients, and no effective treatments are yet available. This parasite possesses a single fatty acyl-CoA binding protein (CpACBP1) that is localized to the unique parasitophorous vacuole membrane (PVM). The major goal of this study was to identify inhibitors from known drugs against CpACBP1 as potential new anti-Cryptos...

Objectives We investigated the relationship between the expression of tumor necrosis factor-inducible gene 6 (TSG-6) with inflammation and integrity of the bladder epithelium in the bladder tissues of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and the mechanism of action using a rat model of BPS/IC. Materials and Methods Expression of TSG-6 and uroplakin III was determ...

This study investigates the clinicopathological features of acute experimental streptococcosis in red tilapia using various routes of infection; intraperitoneal (IP), immersion (IM) and immersion cut (IC). Twenty four red tilapia in duplicates were inoculated intraperitoneally with 10(9) CFU/ml of S. agalactiae while another sets: intact, one with sharp cut at the tail end were exposed to bacte...

conclusions it was the first study that attempted to detect the insertion elements isaba and ic lineages in mdr-ab species isolated from patients with burning in iran. background multidrug resistant strains of acinetobacter baumannii (mdr-ab) have emerged as alarming nosocomial pathogens among patients with burning. objectives the current study aimed to determine the susceptibility of a. bauman...

The objectives of this study were: (i) to investigate the possible role of T-type Ca(2+) channels on the acrosome reaction (AR) of human spermatozoa; and (ii) to determine the sub-type of T-type calcium channels involved in the AR. The AR was induced in vitro by mannose-bovine serum albumin (BSA). The inhibitory effects of mibefradil (T-type Ca(2+) channel blocker), NiCl(2), or nifedipine (L-ty...

Viral gastroenteritis is one of the most common illnesses in humans worldwide [1]. Noroviruses (NoVs) are considered as the major cause of acute gastroenteritis in both children and adults in community-based gastroenteritis, and responsible for sporadic cases and several outbreaks in various epidemiological settings, including restaurants, schools, day-care centers, hospitals, nursing homes and...

Introduction: The TP53 and CHEK2 genes have been described as breast cancer susceptibility some of their polymorphisms associated with an increased risk in certain populations.Aim: objective this study was to investigate the p.R72P PIN3 Ins16bp (TP53) I157T (CHEK2) mutation developping cancer. Methods: This case-control had enrolled 144 participants including 65 cases (breast patients) 79 contr...

Laboratoire de Biologie Cellulaire et Mol~culaire, Centre Hospitalier Universitaire de Poitiers, 86021 Poitiers Cedex, France Allogeneic bone marrow transplantat ion (BMT) is now a c o m m o n t rea tment for hematological diseases. Before the transplantation, the hemopoiet ic cells of the patient are eradicated. In spite of this pretransplant treatment, some apparently normal recipient hemopoi...