نتایج جستجو برای: hypoxia ischemia
تعداد نتایج: 133254 فیلتر نتایج به سال:
Plasma membrane disruption is a characteristic feature of cell death induced by hypoxia or ischemia. Here, we investigated whether analysis of tissue electrical impedance allows detection of ongoing cell membrane rupture and necrotic cell death in hypoxic or ischemic myocardium. Twenty-eight isolated rat hearts were submitted to 5 h of ischemia (n = 8) or hypoxia (n = 20). Myocardial electrical...
Hypoxia from birth increases resistance to myocardial ischemia in infant rabbits. We hypothesized that increased cardioprotection in hearts chronically hypoxic from birth persists following development in a normoxic environment and involves increased activation of nitric oxide synthase (NOS) and ATP-dependent K (K(ATP)) channels. Resistance to myocardial ischemia was determined in rabbits raise...
References 313 In Chap. 13 we described the sequelae of disturbances of the pure primary insults of hypoxia, ischemia, and hypoglycemia. Under common pathologic conditions, a combination of different types of metabolic disturbances regularly occurs. The clinical and morphological features, therefore, may partly overlap. This overlapping of processes is especially important in surviving victims,...
Cerebral ischemic injury has been the leading cause of death and long term disability in the world because of the lack of successful therapies to it, leading to neurological and behavioral deficits. The present study aims to investigate the effects of combined preconditioning (PC) with hypoxia and GYKI-52466 (GYKI) on cerebral ischemic injury and to explore the mechanism. The results showed tha...
An Experimental Model of Brain Ischemia Combining Hypotension and Hypoxia • A variety of experimental models for cerebral ischemia are currently available, but none are entirely satisfactory. We are reporting a model which combines hypotension, produced by intravenous Arfonad, with hypoxia, produced by respiring 4% oxygen. Rabbits used are awake but paralyzed with succinylcholine and ventilated...
The aim of this study was to investigate the tolerance of failing myocardium from postinfarction rats to simulated ischemia. Myocardial infarction (MI) was induced by ligation of the left coronary artery in male Wistar rats. Isometric force and free intracellular Ca(2+) concentration ([Ca(2+)](i)) were measured in isolated left ventricular papillary muscles from sham-operated and post-MI animal...
The increasing demands for personalized targeted therapy directed against renal cell carcinoma have driven a search predictive markers. Novel therapies targeting HIF-1α in been developed, and has suggested as novel marker of response to therapy. surgical resection kidney tumor induces tissue ischemia, is an oxygen-sensitive transcription factor, which known be upregulated during hypoxia. This s...
Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention whereby brief episodes of ischemia/reperfusion of one organ (limb) mitigate damage in another organ (brain) that has experienced severe hypoxia-ischemia. Our aim was to assess whether RIPostC is protective following cerebral hypoxia-ischemia in a piglet model of neonatal encephalopathy (NE) using magnetic resonan...
introduction: stroke is one of the most important reasons of death. hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. the ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. the a1 adenosine receptoras an endogenous l...
The cardiovascular and respiratory systems play key roles in O(2) homeostasis. Physiological responses to hypoxia involve changes in gene expression that are mediated by the transcriptional activator hypoxia-inducible factor (HIF)-1. Analysis of mice heterozygous for a knockout allele at the locus encoding the O(2)-regulated HIF-1alpha or HIF-2alpha subunit has revealed that these proteins are ...
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