نتایج جستجو برای: hypoxia
تعداد نتایج: 57882 فیلتر نتایج به سال:
Introduction: Previous studies have shown altered levels of n-3LCPUFA in the pathophysiologcal conditions such as preeclampsia .Also elevated expression of sFlt-1 in preeclampsia plays a major role in the pathogenesis of this serious disorder especially in reduced placental oxygenation. The present study examines the hypothesis that Eicosapentaenoic acid (EPA 20:5), an omega-3 long-chain polyun...
Abstract Diffuse midline gliomas (DMGs) are the most challenging to treat pediatric high-grade gliomas, with a dismal prognosis of 9 15 months median survival. The ones localized in pons not accessible surgery and rely on radiotherapy treatment. majority DMGs confer mutation histone 3 variants (H3.3 or H3.1), leading lysine 27 methionine substitution (H3K27M) consequent global decrease H3K27 tr...
Abstract Background One of the most prevalent causes fetal hypoxia leading to stillbirth is placental insufficiency. Hemodynamic changes evaluated with Doppler ultrasound have been used as a surrogate marker hypoxia. However, evaluation cannot be performed continuously. As first step, present work aimed evaluate performance miniaturized electrochemical sensors in continuous monitoring oxygen an...
Introduction: Oxygen tension is one of the most important stimuli in stem cell biology. In this study, we investigate the considerable influence of hypoxia on CX43 gene expression as one of the most important gap junction on the surface of mesenchymal stem cells. Methods: Mesenchymal stem cells were isolated from C57BL/6 mouse bone marrow and cultured in DMEM medium under low oxygen tension (...
Considering the incidence of meconium-stained amniotic fluid (MSAF) in newborns and its complications, and also based on indirect reports pointing out relationship between nucleated red blood cell (nRBC), as a marker of chronic hypoxia, and MSAF in term newborns, and in order to determine this relationship more accurately, this study was done on women with uncomplicated singleton term pregnancy...
Collective cell migration is a key feature of transition ductal carcinoma in situ (DCIS) to invasive (IDC) among many other cancers, yet the microenvironmental factors and underlying mechanisms that trigger collective remain poorly understood. Here, we investigated two factors, tumor-intrinsic hypoxia tumor-secreted (secretome), as triggers using three-dimensional (3D) discrete-sized microtumor...
Angiogenesis, as the process of new vessel formation from pre-existing vessels is dependent on a delicate equilibrium between endogenous angiogenic and antiangiogenic factors. However, under pathological conditions, this tight regulation becomes lost which can result in the formation of the different diseases such as cancer. Angiogenesis is a complex process that includes many gene products tha...
Introduction. Intrauterine hypoxia is one of the most frequent complications in pregnancy. It risk factors fetal development disorders. In antenatal period, effects on re-productive system can impair fetus and lead to negative consequences. The aim was studypathological functional features testes different periods gestation with chronic intrauterine hypoxia. Materials methods. We examined autop...
Abstract Background Hypoxia, low oxygen, is a microenvironment that promotes tumour progression, particularly in gliomas. The regulation of many biological processes are maintained by miRNAs. hypoxia status glioma cells effects the affecting expression individual miRNAs.The aims this study identifying significant miRNAs either under or overexpressed compared to normoxia and further exploring ef...
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