INTRODUCTION REPRODUCTIVE PHYSIOLOGY ANTERIOR PITUITARY TESTES FEEDBACK CONTROL OF GONADOTROPINS PROLACTIN AND GONADOTROPINS ANDROGEN PHYSIOLOGY HORMONAL CONTROL OF SPERMATOGENESIS DIAGNOSING ENDOCRINE ABNORMALITIES: CLINICAL FINDINGS SEMEN ANALYSIS BASELINE HORMONE EVALUATION DYNAMIC HORMONAL TESTING CLASSIFICATION OF ENDOCRINE CAUSES OF INFERTILITY PRIMARY HYPOGONADISM SECONDARY HYPOGONADISM ...

Testosterone supplementation therapy (TST) is a widely used treatment for men with late onset hypogonadism. The benefits seen with TST, such as improved libido and energy level, beneficial effects on bone density have been well documented. Although hypogonadism remains an independent risk factor for mortality, recent studies have examined the association between testosterone therapy and cardiov...

CONTEXT Although the behavioral effects of high-dose androgen administration may involve alterations in serotonergic activity, few studies have investigated the impact of androgen withdrawal on the central nervous system in humans. OBJECTIVE To examine the effects of pharmacologically induced hypogonadism on several cerebrospinal fluid (CSF) systems that could mediate the behavioral concomita...

OBJECTIVE After the demonstration that one-third of male patients with type 2 diabetes have hypogonadotrophic hypogonadism, we have shown that patients with hypogonadotrophic hypogonadism also have markedly elevated C-reactive protein (CRP) concentrations. We have now hypothesized that type 2 diabetic subjects with hypogonadotrophic hypogonadism may have a lower hematocrit because testosterone ...

Similar to many other endocrinologic disease states, hypogonadism is a multifactorial disorder with clinical sequelae that reach well beyond those of just androgen deficiency. This syndrome results from failure of the testes to produce physiological levels of testosterone due to disruption of 1 or more levels of the hypothalamic-pituitary-gonadal axis. The condition affects 2 to 4 million men i...

OBJECTIVE Deficiency of sex steroids has a negative impact on bone mineral content. In studies conducted on postmenopausal women and animal studies, elevated follicle-stimulating hormone (FSH) levels were found to be correlated with a decrease in bone mineralization and osteoporosis. The aim of the present study was to evaluate bone mineral density (BMD) in adolescent girls with hypogonadotropi...

Secretion of the alpha-subunit of pituitary glycoprotein hormones usually follows the secretion of intact gonadotropins and is increased in gonadal failure and decreased in isolated gonadotropin deficiency. The aim of the present study was to determine the levels of the alpha-subunit in the serum of patients with cirrhosis of the liver and to compare the results obtained for eugonadal cirrhotic...

UNLABELLED Low BMDs, short stature, hypogonadism, subclinical hypothyroidism, and IFG are found in 3.3, 10, 33, 16.6, 6.6, and 26.6 % of 30 pediatric β thalassemia major patients, respectively. Age is related with low Z-scores. Short stature and hypogonadism patients were older. These patients' monitoring in late childhood and early teenage for these complications is recommended. BACKGROUND B...

This article contains a review of the clinical aspects of testosterone replacement in androgen deficiency of the aging male.