Increased glycolysis is the principal explanation for how cancer cells generate energy in the absence of oxygen. However, in actual human tumour microenvironments, hypoxia is often associated with hypoglycemia because of the poor blood supply. Therefore, glycolysis cannot be the sole mechanism for the maintenance of the energy status in cancers. To understand energy metabolism in cancer cells u...

Beta-glucans are soluble fibers with physiological functions, such as interference with absorption of sugars and reduction of serum lipid levels. The objective of the present study was to analyze the distribution of beta-glucans in different tissues of the African grass species Rhynchelytrum repens and also to evaluate their hypoglycemic activity. Leaf blades, sheaths, stems, and young leaves o...

OBJECTIVE The central nervous system mechanisms of defenses against falling plasma glucose concentrations, and how they go awry and result in iatrogenic hypoglycemia in diabetes, are not known. Hypoglycemic plasma glucose concentrations of 55 mg/dL (3.0 mmol/L) cause symptoms, activate glucose counterregulatory systems, and increase synaptic activity in a network of brain regions including the ...

AIM The present study was designed to investigate the activity of two glibenclamide derivatives on glucose concentration. An additional aim was to identify the biodistribution of glibenclamide derivatives in different organs in a diabetic animal model. METHODS The effects of two glibenclamide derivatives on glucose concentration were evaluated in a diabetic animal model. In addition, glibencl...

in an effort to evaluate the hypoglycemic activity of t. polium, the crude extract was administered orally to a group of streptozotocin induced diabetic rats for 6 consecutive weeks. significant decrease in blood glucose by 64%, total bilirubin by 35%, glutamate oxaloacetate transferase by 48% and glutamate pyruvate transferase by 30% was observed compared to untreated diabetic rats. however, t...

Diabetes is a long-term (chronic), challenging lifestyle (metabolic) disorder in which the body cannot regulate amount of sugar blood and majorly affecting endocrine system metabolic functions. Its complications affect neurons (as developing neuropathy), kidney nephropathy), eye retinopathy). also results other associated problems, such as diabetic foot ulcers, sexual dysfunction, heart disease...

In this study, a novel polysaccharide, LPP, was obtained from Lonicera caerulea L. pomace by ultrasonic-assisted heating and purified Sephadex G-100. The structural characteristics of LPP showed that the molecular weight (Mw) 8.53 × 104 Da; it mainly composed galacturonic acid, followed galactose; possessed characteristic functional groups polysaccharides; had an absence O-glycosidic bonds crys...