OBJECTIVES An estimated 6%-10% of US adults took a hypnotic drug for poor sleep in 2010. This study extends previous reports associating hypnotics with excess mortality. SETTING A large integrated health system in the USA. DESIGN Longitudinal electronic medical records were extracted for a one-to-two matched cohort survival analysis. SUBJECTS Subjects (mean age 54 years) were 10 529 patie...

THIS review will treat the more commonly prescribed hypnotic agents and their sleep-inducing properties. Hypnotic agents that are seldom used (paraldehyde), drugs that are not singularly soporific but may be used either alone or as adjuncts in inducing sleep [e.g. meprobamate (Equanil, Miltown), chlordiazepoxide (Librium) and diazepam (Valium)] and drugs that have little soporific effect [antih...

In this study, we investigated the sedative and hypnotic effects of the aqueous extract of Aloe vera on rats. In order to evaluate the overall hypnotic effects of the Aloe vera extract, open field and loss of righting reflex tests were primarily used. The sedative and hypnotic effects of the extract were then confirmed by detection of remarkable raise in the total sleeping time through analysis...

This study describes the development and preliminary psychometric properties of a scale for measuring hypnotic response in clinical hypnosis sessions. The Hypnotic State Assessment Questionnaire (HSAQ), a brief, multidimensional measure of hypnotic response during clinical sessions of hypnosis, is intended to facilitate supervision of hypnosis trainees and to document subjects' response in clin...

Background Hypnotic use in children and adolescents is controversial. Objective To describe the of hypnotic drugs (melatonin, z-drugs, sedating antihistamines) among 5- to 24-year-old Scandinavians during 2012 2018. Methods Aggregate-level data were obtained from public sources Sweden, Norway, Denmark. We calculated annual prevalence (users/1000 inhabitants) stratified by age group, sex, countr...

Background and aims: The aim of the study was to evaluate the effect of melatonin administration on sleep and behavioral disorders in the elderly and the facilitation of the discontinuation of regular hypnotic drugs. Methods: This was a prospective, randomized, double-blind, placebo-controlled, crossover trial in a community-living population. Participants were 22 older adults (7 men, 15 women ...

Very highly hypnotizable subjects are rare, easily induced, and able to manifest the whole spectrum of hypnotic phenomena, including post-hypnotic amnesia. The aim of this study was to detect and localize by means of quantitative functional MRI and EEG changes in cortical activity during hypnosis induction and deep "pure hypnosis" in a hypnotic "virtuoso" subject. We focused on areas forming th...