Scars are a result of the natural healing process that occurs when the skin repairs itself after wounds, trauma, burns, surgical incision, or disease. Normal skin tissue is replaced with scar tissue to close open wounds and prevent infection. Scars can be painful, cause itching, and limit mobility. Many scars are primarily a cosmetic concern, but their presence may have a significant negative i...

BACKGROUND How a scar is managed postoperatively influences its cosmetic outcome. After suture removal, scars are susceptible to skin tension, which may be the trigger for hypertrophic scarring. Paper tape to support the scar may reduce multidirectional forces and prevent hypertrophic scarring. METHODS Seventy patients who had undergone cesarean section at the Royal Brisbane and Women's Hospi...

1. Sigwart U. Non-surgical myocardial reduction for hypertrophic obstructive cardiomyopathy. Lancet 1995;346:211–214. 2. Lakkis N, Nagueh SF, Kleiman NS, Killip D, He ZX, Verani MS, Roberts R, Spencer WH III. Echocardiography-guided ethanol septal ablation for hypertrophic obstructive cardiomyopathy. Circulation 1998;98: 1750–1755. 3. Knight C. Alcohol septal ablation for obstructive hypertroph...

BACKGROUND Hypertrophic cardiomyopathy, a familial myocardial condition caused by sarcomere protein mutations, is usually recognized by early adulthood. Hypertrophic cardiomyopathy of the elderly has similar clinical features but, notably, a later age of onset and noncontributory family history. Causes of elderly-onset hypertrophic cardiomyopathy are unknown. METHODS AND RESULTS Eighteen wome...

Metaphyseal chondrodysplasia, Schmid type (MCDS) is characterized by mild short stature and growth plate hypertrophic zone expansion, and caused by collagen X mutations. We recently demonstrated the central importance of ER stress in the pathology of MCDS by recapitulating the disease phenotype by expressing misfolding forms of collagen X (Schmid) or thyroglobulin (Cog) in the hypertrophic zone...

An active, healthy, and symptom free 16 year old boy with a family history of hypertrophic cardiomyopathy died suddenly while walking home from school. Necropsy showed absence of left ventricular hypertrophy (that is, normal heart weight), though the characteristic histological abnormalities of hypertrophic cardiomyopathy, such as cardiac muscle cell disorganisation and abnormal intramural coro...

In 1957, Brock 1 described 3 patients with hypertrophic cardiomyopathy of which one of these patients had previously been hypertensive. Brock postulated that obstruction of the left ventricle outflow tract was caused by concentric hypertrophy of the subvalvular region of the left ventricle, which in turn resulted in sustained systemic hypertension. Later in 1970, Hambly 2 reported 8 cases of hy...