نتایج جستجو برای: hyperphagia

تعداد نتایج: 1289  

Journal: :The Journal of Clinical Endocrinology & Metabolism 2011

Journal: :Journal of Veterinary Medical Science 1999

2016
Damon T Jacobs Luciane M Silva Bailey A Allard Michael P Schonfeld Anindita Chatterjee George C Talbott David R Beier Pamela V Tran

Primary cilia extend from the plasma membrane of most vertebrate cells and mediate signaling pathways. Ciliary dysfunction underlies ciliopathies, which are genetic syndromes that manifest multiple clinical features, including renal cystic disease and obesity. THM1 (also termed TTC21B or IFT139) encodes a component of the intraflagellar transport-A complex and mutations in THM1 have been identi...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Harumi Harada Eiji Warabi Taizo Matsuki Toru Yanagawa Kosuke Okada Junya Uwayama Akira Ikeda Kazuhiro Nakaso Kyoko Kirii Noriko Noguchi Hiroki Bukawa Richard C M Siow Giovanni E Mann Junichi Shoda Tetsuro Ishii Takeshi Sakurai

The cytoplasmic regulatory protein p62 (Sequestosome 1/A170) is known to modulate various receptor-mediated intracellular signaling pathways. p62 deficiency was shown to result in mature-onset obesity in mice, but the mechanisms underlying this abnormality remained unclear. Here we report that hyperphagia due to central leptin resistance is the cause of obesity in p62(-/-) mice. We found that t...

Journal: :Diabetes 2003
Tooru M Mizuno Kevin A Kelley Giulio M Pasinetti James L Roberts Charles V Mobbs

Hypothalamic proopiomelanocortin (POMC) gene expression is reduced in many forms of obesity and diabetes, particularly in those attributable to deficiencies in leptin or its receptor. To assess the functional significance of POMC in mediating metabolic phenotypes associated with leptin deficiency, leptin-deficient mice bearing a transgene expressing the POMC gene under control of the neuron-spe...

Journal: :European journal of endocrinology 2004
A M Holm P B Johansen I Ahnfelt-Rønne J Rømer

OBJECTIVE The aim was to investigate the possible interactions of the two peripheral hormones, leptin and ghrelin, that regulate the energy balance in opposite directions. METHODS Leptin-receptor mutated Zucker diabetic fatty (ZDF) and lean control rats were treated with the ghrelin-receptor ligand, tabimorelin (50 mg/kg p.o.) for 18 days, and the effects on body weight, food intake and body ...

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