OBJECTIVES To develop a process of advance consent to enable research to be undertaken in patients in the terminal phase. DESIGN Feasibility study of an advance consent process to support a randomised controlled trial of two antimuscarinic drugs (hyoscine hydrobromide and glycopyrronium bromide) in the management of noisy respirations associated with retained secretions ("death rattle"). SE...

purpose: oculocardiac reflex (ocr) is a frequent event during strabismus surgery. the aim of this study is to compare the preventive effect of intravenous lidocaine and hyoscine on ocr.methods: this prospective, randomized clinical trial was performed on 75 patients (5-63 years old) underwent strabismus surgery. patients divided randomly into three groups. intravenous hyoscine (0.2 mg/kg), lido...

The aza-Michael addition of 1,2,3,6-tetrahydrophthalimide with symmetrical fumaric esters has been performed efficiently in a solvent-free system at 100 °C and using 1,4-diazabicyclo[2.2.2]octane (DABCO) as a base in the presence of tetrabutylammonium bromide (TBAB). The products were obtained in good to high yields within 2.5-7.0 h. This reaction worked well on linear alkyl fumarates and was n...

Reaction of n-propylamino-N,N-bis(2-methylene-4-tert-butyl-6-methylphenol), H(2)L1, n-propylamino-N,N-bis(2-methylene-4,6-di-tert-butylphenol), H(2)L2, and benzylamino-N,N-bis(2-methylene-4-tert-butyl-6-methylphenol), H(2)L3, with anhydrous ferric chloride in the presence of base yields the products, [FeL1(μ-Cl)](2) (1), [FeL2(μ-Cl)](2) (2) and [FeL3(μ-Cl)](2) (3). In the solid state, these com...

Liquid membrane processes have attracted many interests in recent years for removal of heavy metals such as cadmium from industrial wastewaters. In this study, a modified hybrid liquid membrane system is introduced. The setup is worked by applying the water-insoluble dioctyl phthalate as the organic solvent. N-octanol and tetra butyl ammonium bromide are added to the organic phase to increase t...

The title compound, C(20)H(19)N(3)O(3)·C(3)H(7)NO, was synthesized by the reaction of 6-amino-pyrimidine-2,4(1H,3H)-dione and 4-methyl-benzaldehyde with 5,5-dimethyl-1,3-cyclo-hexa-nedione in 1-butyl-3-methyl-imidazolium bromide at 363 K. The pyrimidine ring adopts a half-chair conformation while the six-membered ring fused to the pyridine ring adopts a skew-boat conformation. The dihedral angl...

The aims of this study were to determine whether the development of acid induced duodenal ulcer pain was influenced by the symptomatic status of the patient and whether the administration of an antispasmodic could abolish pain. One hundred millilitres of 0.1 N hydrochloric acid was infused onto the ulcer craters or scars of 143 duodenal ulcer patients on 168 occasions. Symptomatic patients were...

       Volatile constituents of the seed kernel and leaf of cultivated Moringa peregrina (Forssk.) Fiori, Agricolt collected after hydrolysis were analyzed by GC and GC/MS. Five glucosinolate degradation products which constituted almost the whole isolated oil of the seed kernel were identified to be: isobutyl isothiocyanate (94.0%), isopropyl isothiocyanate (4.9%), sec-butyl isothiocy...

a simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([bmim]br) under solvent-free conditions is reported. the presented method is benefited from operational simplicity,...