Chloral hydrate and hydroxyzine are a drug combination frequently used by practitioners to sedate pediatric dental patients, but their effectiveness has not been compared to a negative control group in humans. The aim of this crossover, double-blinded study was to evaluate the effect of these drugs compared to a placebo, administered to young children for dental treatment. Thirty-five dental se...

We would like to thank Koniari et al.1 for the interest demonstrated in our manuscript. We have reported the case of an 85-year-old male who developed type 1 Kounis syndrome (coronary spasm) after administration of ciprofloxacin.2 The authors pointed out the potential role of the combined effect of the drugs the patient was taking (hydroxyzine and alprazolam). Indeed, they cited case reports of...

There are a few reports in the literature implicating them causing fixed drug eruption, piperazine derivatives. In this case, although eszopiclone for insomnia medicinehas ring, no eruption appeared so far. Oxatomide and hydroxyzine not only shared ring but also two benzene rings via methine group (=CH–). It was suspected that structural became an antigenic determinant resulted cross-reactivity...

Acquired neuromuscular weakness often develops in patients with an acute respiratory distress syndrome (ARDS), particular who are ventilated and sedated for long periods. This has been rarely described the literature on ARDS secondary to SARS-CoV-2 infection. Our clinical case revealed existence of these manifestations COVID-19 disease after use hydroxyzine, antihistamine whose side-effects unk...

Derivative spectrophotometric, colorimetric and high performance liquid chromatographic methods, for the determination of the antihistaminic cetirizine dihydrochloride in tablet form were described. Spectrophotometrically, cetirizine was determined by the measurement of its first (1D) and second (2D) derivative amplitudes at 239 (peak) and 243-233 nm (peak-to-trough), respectively. The aqueous ...

In this work, we have used cyclic voltammetry to investigate the interfacial behavior of cocaine cutting agents at electrified liquid-liquid interface formed between a solution water and 1,2-dichloroethane phases. Among 27 chemical species adulterate street samples, only 8 were detectable in available potential window. These include procaine, lidocaine, levamisole, hydroxyzine, caffeine, phenyl...

Idiopathic anaphylaxis in the pediatric population is being increasingly recognized, with symptoms (and therefore classifications) the same as those described in adults. We present a series of 22 patients with special attention to considerations relatively unique to the pediatric population. Prednisone, hydroxyzine, and albuterol were used to control symptoms and induce remission. No deaths occ...

PURPOSE This study was performed to compare the effects of nitrous oxide/oxygen (N2O/O2) versus oxygen (O2) as adjuncts to an oral narcotic regimen for pediatric conscious sedation. METHODS Using a randomized double-blind crossover design, 19 children (mean age 41 +/- 8.6 months) were sedated with chloral hydrate (50 mg/kg), meperidine (1.5 mg/kg) and hydroxyzine pamoate (25 mg) for two appoi...